Property | Value |
Name | COMPUTATIONAL SCREENING OF HERBAL LEAD COMPOUNDS AND ANALOGS AGAINST ATAXIN 3 AND TAU |
Description | Research article:- * Sayak Ganguli, Rahul Banik, Aditi Gangopadhyay and Abhijit Datta .
DBT CENTRE FOR BIOINFORMATICS, PRESIDENCY UNIVERSITY, 86/1 College Street, Kolkata 700073 India.
Abstract :- Machado-Joseph Disease and Alzheimer’s disease both are neurodegenerative disorders. MJD or SCA3 is a movement disorder and AD patients suffer from mental illness, depression, and dementia. MJD belongs to a class of genetic disorder called triplet repeat diseases. The mutant gene possesses increased number of CAG trinucleotide repeat which produces a mutated protein called ATAXIN3 and AD and this is due to hypophosphorylated microtubule associated protein Tau. The two proteins were modeled using modeller and then checked for protein quality. Then herbal lead compounds and their analogs were identified and screened with the target protein and energy values were compared. Results indicate that more than one herbal lead compounds could serve as potent inhibitors of mutated Tau and ATAXIN.
Keywords:- ATAXIN3, Tau, Modeller, Docking, ChemSketch, Herbal Ligands, Analogs |
Filename | Ganguli Sayak et. al..pdf |
Filesize | 769.08 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 11/17/2011 00:00 |
Viewers | Everybody |
Maintained by | Editor |
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Last updated on | 12/17/2011 08:04 |
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