Property | Value |
Name | Formulation of Clotrimazole as lozenge tablet for improved delivery to ORAL thrush |
Description | Research article:- *Nagoba Shivappa N.1 , Purushotham Rao K.2, Zakaullah S.3 .
1Karpagam University, Coimbatore (T.N.) India. 2H.K.E.’s College of Pharmacy, Gulbarga (Karnataka) India. 3Al-Badar Rural Dental College & Hospital, Gulbarga (Karnataka) India.
Abstract:- The present investigation aims to design, prepare and evaluate the medicated candy based tablet lozenges of Clotrimazole for paediatric, geriatric and Dysphagic patients and to investigate the suitability of Isomalt and/or liquid glucose as the sugar substitute in the prepared lozenges. The candy based lozenges were prepared by heating and congealing method in a candy based industry on request with sugar base, Acacia, citric acid artificial flavours and colours and other essential excipients. The prepared medicated lozenges were characterized for drug content uniformity, hardness, thickness, weight variation, friability, moisture content, in vitro disintegration and dissolution by pharmaceutical standard methods. Accelerated stability study conducted as per ICH guidelines (zone IV) at 45°C and 75% relative humidity over a period of seven weeks found that there wasn’t any substantial interaction between the drugs, flavor and color and the prepared formulations were stable.
Keywords:- Clotrimazole, lozenges, oral thrush. |
Filename | N Shivappa Nagoba et al..pdf |
Filesize | 296.65 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 11/17/2011 00:00 |
Viewers | Everybody |
Maintained by | Editor |
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Last updated on | 12/17/2011 08:01 |
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