Property | Value |
Name | Influence of Various Processes and Additives on the Performance of Perindopril Fast Disintegrating Tablets |
Description | Research article:- Harika K, Sunitha K, Pavan Kumar P, Arjun N and Madhusudan Rao Y*
Department of Pharmaceutics, National facilities in Engineering and Technology with Industrial Collaboration (NAFETIC) centre, University College of Pharmaceutical Sciences, Kakatiya University, Warangal – 506 009, A.P. India.
Abstract:-The intention of present study was to practice and evaluate fast disintegrating tablets containing antihypertensive drug i.e., Perindopril ter-butyl amine in a convenient dosage form for ease of administration and to accomplish better patient compliance. This study emphasizes on the various processes (wet granulation, compression granulation, direct compression and freeze drying techniques) adopted for the fabrication of fast disintegrating tablets, effect of superdisintegrants such as sodium starch glycolate, crospovidone and croscarmellose sodium at three levels and other additives like microcrystalline cellulose, sodium stearyl fumarate in different proportions on in–vitro and in-vivo disintegration time, wetting time and water absorption ratio. The tablets were tested for taste, weight and thickness variation, hardness, uniformity of dosage units, in-vitro and in-vivo disintegration time, and in-vitro drug release. The in‐vitro release of Perindopril was performed under sink conditions (0.1N HCl, 37±0.5 ºC, rpm 50) using USP TYPE -II dissolution apparatus. Results from taste evaluation in human volunteers revealed that the FDTs with taste-improved formulations containing aspartame had significantly enhanced palatability, improved mouth feel and reduced grittiness. The best in-vitro and in-vivo disintegration time (DT) was achieved with the formulation containing crospovidone and freeze dried formulation was found to be 20sec & 10sec and 28sec & 11sec, respectively. The results revealed that the tablets prepared by freeze drying method had a good dissolution profile with more than 90% of drug release within 30sec. Next to freeze drying method, formulation (P8) with 4% crospovidone showed complete drug release at the end of 3min. DSC and FT-IR studies did not show any evidence of interaction between the drug and the excipients although when formulated in various formulation methods. The stability studies showed that optimized formulation was considered to be highly stable.
Key words : Fast disintegrating tablets; freeze drying; Perindopril ter-butyl amine; superdisintegrants. |
Filename | Rao Madhusudan Y et.al..pdf |
Filesize | 808.07 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 10/17/2011 00:00 |
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Last updated on | 12/20/2011 14:18 |
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