Property | Value |
Name | The CD4 cell count recovery in HIV and tuberculosis co-infected patients versus tuberculosis uninfected HIV patients in a tertiary care Hospital |
Description | Research article:- *Dr. Narayan Shrihari MD (Microbiology)1, Dr. KumudiniT.S D.Bact (Microbiology) 2, Dr. Mariraj. J MD (Microbiology) 3, Dr. Krishna.S MD (Microbiology) 4 1Asst. Professor, Department of Microbiology, Vijayanagar Institute of Medical Sciences (VIMS), Bellary-583104, India. 2 Tutor, Department of Microbiology, Vijayanagar Institute of Medical Sciences (VIMS), Bellary-583104, India. 3 Professor, Department of Microbiology, Vijayanagar Institute of Medical Sciences (VIMS), Bellary-583104, India. 4 Professor and Head, Department of Microbiology, Vijayanagar Institute of Medical Sciences (VIMS), Bellary-583104, India.
Abstract:- Introduction: Human Immunodeficiency Virus (HIV) infected patients have an increased risk of developing tuberculosis (TB) due to a loss of cell mediated immunity, along with a quantitative decline in circulating CD4 lymphocytes and tuberculosis occurs sooner than other opportunistic infections. The dual (HIV/TB) infection compared with CD4 matched cohort of TB uninfected HIV patients. We sought to test the hypothesis; TB additionally contributes to reduction in CD4 count in HIV/TB co-infected patients and leads to greater improvement in count following treatment as compared to CD4 matched TB uninfected individuals. Material and Methods: This is a retrospective cohort study. We studied the change in CD4 cell count in two groups of patients, those with CD4 cell count >200 cells/mm3 (Group 1) and < 200 cells/mm3 (Group 2) at presentation. In each group the change in CD4 cell count in dually infected patients following six months anti-tuberculosis therapy (ATT) and anti-retroviral therapy (ART) was compared to cohort of CD4 matched TB uninfected patients only on ART. Results: In group1 (156 cases) dually infected patients CD4 count improved from 250 to450 cells/mm3 and in TB uninfected (control) patients the change was from 260 to422 cells/mm3. In group 2 (180 cases) dually infected subjects count improved from 150 to355 cells/mm3, where as in TB uninfected (control) patients improvement was from 170 to330 cells/mm3. Conclusion: Greater improvement in CD4 count with ATT and ART in dually infected patients, it may suggests that TB additionally influences the reduction of CD4 count in HIV patients.
Keywords:-Anti-tuberculosis therapy, anti-retroviral therapy and CD4 cell lymphocyte of cryptosporidiosis in HIV infected patients and simple method modified ZN staining can detect oocyst in stool sample. |
Filename | Shrihari Narayan et. al.(2).pdf |
Filesize | 213.64 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 12/17/2011 00:00 |
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Last updated on | 01/10/2012 08:25 |
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