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Name | Antibiotic susceptibility pattern of urinary isolates with special reference to Ciprofloxacin resistance in a Tertiary care hospital |
Description | Research article:- *S. Mathavi1, G. Sasikala1, A. Kavitha1, K.R. Rajesh2, Indra Priyadharsini2 1Asst. Professor, Department of Microbiology, Kirupananda Variyar Medical College, Seeragapadi, Salem- 636308. Tamilnadu, India. 2 Professor, Department of Microbiology, Kirupananda Variyar Medical College, Seeragapadi, Salem- 636308. Tamilnadu, India.
Abstract: Background: Urinary tract infections (UTIs) are the second most common infections in community practice. Fluoroquinolones are the preferred antimicrobial agents for empirical therapy of UTI. Ciprofloxacin is the most frequently prescribed fluoroquinolone for UTI because of its excellent activity against uropathogens. Decreased susceptibility to fluoroquinolones arises mainly by single-step mutations in the gyrA and parC genes, which encode the fluoroquinolones targets, the topoisomerase enzymes, conferring cross-resistance to fluoroquinolones. Aim: This study was undertaken to evaluate the susceptibility of urinary isolates to various antibiotics and to know the prevalence of ciprofloxacin resistance among urinary isolates and guide the clinicians to prescribe the most successful empirical antibiotic to eliminate the urinary pathogens. Materials & Methods: A total of 532 isolates obtained from urine samples received in the microbiology department over a period of six months (March-August 2011) were subjected to antibiotic susceptibility testing. Isolates with resistance or with decreased susceptibility to Ciprofloxacin (≤20 mm) were then screened for minimum inhibitory concentration (MIC) by E-test. Results: Out of 532 isolates, 112 (21%) isolates were resistant to Ciprofloxacin. The MIC of these isolates ranged from 4 to > 32µg/ml. Conclusion: The increased use of fluoroquinolones as empirical treatment for the UTIS will facilitate the emergence of resistance to this class of compounds and promote the emergence of multi-drug resistant strains. Hence it should be discouraged as it will undermine the efficacy of fluoroquinolones to treat more serious infections. This study hence emphasizes the need for the continuous evaluation of the commonly used antibiotics.
Keywords: Ciprofloxacin, Fluoroquinolones, MIC, Urinary isolates. |
Filename | Mathavi S et. al..pdf |
Filesize | 220.17 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 12/16/2011 00:00 |
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Maintained by | Editor |
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Last updated on | 01/10/2012 11:17 |
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