Property | Value |
Name | VALIDATING NUTRACEUTICALS TO ALLEVIATE PROGERIA USING MOLECULAR DOCKING STUDIES |
Description | Research article:- * Jeyam M.1, Sushma R.2, Sharanya M.3, Poornima V.3 *1 Corresponding author, Assistant Professor, Department of Bioinformatics, Bharathiar University, Coimbatore-46, Tamil nadu, India. 2M.Sc. student, Department of Bioinformatics, Bharathiar University, Coimbatore-46, Tamil nadu, India. 3Research Scholars, Biochematics lab, Department of Bioinformatics, Bharathiar University, Coimbatore-46, Tamil nadu, India.
Abstract:-The Hutchinson Gilford Progeria Syndrome is a premature aging disorder in children. Progeria is a cause of progerin accumulation due to mutation in protein lamin A which can be inhibited by blocking the prenylation process. The addition of a farnesyl or geranyl moiety to the CAAX motif of the protein in the post translation step prevents the formation of mutant lamin A. In the present study, the inhibitors were screened for blocking the prenylation process by docking nutraceuticals with the Farnesyl Pyrophosphate Synthase (FPPS) using Autodock. The compound Madecassoside from Centella asiatica showed the least binding energy (-16.11 Kcal/mol) and lower inhibitory constant (1.55 μM) forming 7 hydrogen bond interactions with the active site residues VAL254 (2), LYS257, TYR204 LYS200, ASP243 of FPPS target.
Keywords:-Autodock; Centella asiatica; Nutraceuticals; Progeria; LaminA. |
Filename | Jeyam M et.al..pdf |
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Creator | admin |
Created On: | 01/19/2012 19:23 |
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Last updated on | 01/19/2012 19:25 |
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