Property | Value |
Name | Antimicrobial, Cytotoxicity and Antioxidant Activity of Tinospora crispa |
Description | Research article:-Haque Aminul Md., Islam Ashraful S. M. and Shahriar Mohammad * MS in Pharm. Tech., Lecturer, Department of Pharmacy, University of Asia Pacific, Dhaka-1209, Bangladesh. M. Pharm., Associate Professor, Department of Pharmacy, University of Asia Pacific, Dhaka-1209, Bangladesh. MS in Pharm. Tech., Assistant Professor, Department of Pharmacy, University of Asia Pacific, Dhaka-1209, Bangladesh.
Abstract: Tinospora crispa (family: Menispermaceae) has been investigated for evaluation of the biological activities. The stem bark T. crispa of was extracted with methanol and the extract was partitioned with petroleum ether, carbon tetrachloride, chloroform and aqueous soluble fractions. The chloroform, petroleum ether and methanolic extracts were subjected to antimicrobial screening against some gram-positive and gram-negative organisms by the disc diffusion method. In the brine shrimp lethality bioassay, the extracts of chloroform, petroleum ether and methanol were found to show LC50 of 11.5 g/ml, 12.6 g/ml and 12.0 g/ml respectively. This indicated that the cytotoxicity exhibited by the chloroform, petroleum ether and methanol extract was very significant. These extractives were subjected to antioxidant screening- by DPPH free radical scavenging activity. In these cases, butylated hydroxytoluene (BHT) and ascorbic acid were used as antioxidant standard. By DPPH assay, it is found that the carbon tetrachloride soluble fraction of T. crispa showed strong antioxidant activity with the IC50 value 30 µg/ml. Besides petroleum ether and chloroform soluble fractions also showed free radical scavenging activity with the IC50 value 70 and 75 µg/ml, respectively.
Keywords: T. crispa, extracts, antioxidant activity, cytotoxicity, antimicrobial screening |
Filename | Mohammad Shahriar et.al..pdf |
Filesize | 310.77 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 12/16/2011 00:00 |
Viewers | Everybody |
Maintained by | Editor |
Hits | 11786 Hits |
Last updated on | 01/19/2012 19:30 |
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