Property | Value |
Name | Morphological and Biochemical Effects of Dried Leaves of Carica papaya Linn. (Pawpaw) on the Liver in Wistar Rats. |
Description | Research article:- * SULE, O.J,1 ELEKWA, I.2 and JOFFA, P.P.K3. 1Department of Medical Biochemistry, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria. 2Department of Biochemistry, Abia State University, Uturu, Abia State, Nigeria. 3Department of Physiology, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria.
Abstract:- The role of C. papaya for the prevention of CCl4 induced liver damage was investigated. Thirty wistar albino rats were allotted to six groups. Rats in group1 were fed with 100% feed and administered CCl4, while those in groups (2, 3 and 4) were pretreated with 10%, 30%, and 50% of dried leaves of C. papaya respectively. Rats in groups 5 and 6 received 30% C. papaya and 100% feed without administration of CCl4 (positive and general controls respectively). CCl4 induction was carried out on the 29th day of study (0.5 ml/kg body weight in 0.5 ml olive oil intraperitoneally). Rats were starved for 24hrs, scarified on the 30th day of study and the serum was used to investigate the activities of liver marker enzymes (ALT, AST, ALP, CPK and LDH) using colorimetric methods. Morphology parameters were also assessed. Data obtained were analyzed by inferential statistics using ANOVA. There was significant increases (p ≤ 0.05) in the levels of serum enzymes ( ALT, AST, ALP, CPK and LDH) in CCl4 treated rats when compared with rats groups that were pre-treated with 10%, 30% and 50% C. papaya prior to administration of CCl4. However, there were significant decreases (p ≤ 0.05) in the levels of ALT, AST, ALP, CPK and LDH in rats that were pre-treated with 10%, 30% and 50% C. papaya when compared with the rats that were administered CCl4 only, in a dose dependent manner. Liver weights decreased significantly (p ≤ 0.05) in rats administered with CCl4 only. However, there was significant increase (p ≤ 0.05) in the liver weights of rats that were pre-treated with 10%, 30% and 50% Carica papaya, when compared with the rats that received CCl4 only. Unusual aggressive behavioral display was noticed in the pretreated experimental groups.
Key Words:- Carica papaya (C. papaya), Carbon tetrachloride (CCl4), morphology, wistar rats etc. |
Filename | Sule O J et al..pdf |
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Creator | admin |
Created On: | 02/17/2012 00:00 |
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Last updated on | 03/19/2012 19:00 |
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