Property | Value |
Name | The protective nature of Acalypha wilkensiana muell arg. leaves on CCL4-induced hepatotoxicity in wistar rats. |
Description | Research article:- * SULE, O.J,1 ELEKWA, I.2 and AYALOGU, E.O.3 1Department of Medical Biochemistry, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria. 2Department of Biochemistry, Abia State University, Uturu, Abia State, Nigeria. 3 Department of Biochemistry, University of PortHarcourt, Choba, Rivers State, Nigeria.
Abstract:-The hepatoprotective and antioxidant activities of Acalypha wilkesiana against CCL4-induced hepatotoxicity and oxidative stress in wistar albino rats were assessed. Activities of liver marker enzymes in serum (ALT, AST, ALP, CPK and LDH) were determined colorimetrically using standard kits. Morphology parameters were also assessed. Rats in group1 were fed with 100% feed and administered CCL4, while those in groups (2, 3 and 4) were pretreated with 10%, 30%, and 50% of dried leaves of Acalypha wilkesiana respectively. Rats in group 5 were pretreated with 30% Acalypha wilkesiana without administration of CCL4 (positive control), while rats in group 6 were fed with 100% feed without CCL4 administration (general control). Data obtained were analyzed by inferential statistics using ANOVA. The CCL4 induction (0.5 ml/kg body weight in 0.5 ml olive oil intraperitoneally) on the 28th day of study caused significant increases (p< 0.05) in the levels of serum enzymes (ALT, AST, ALP, CPK and LDH), when compared with the controls. Pre-treatment of rats with 10% and 30% Acalypha wilkesiana for twenty eight (28) days resulted in significant decreases (p< 0.05) in the levels of ALT, AST, ALP, CPK and LDH, in a dose dependent manner. However, there was significant increase (p< 0.05) in the levels of liver marker enzymes as well as significant decreases (p< 0.05) in the body weight changes and liver weights in rats group pretreated with 50% Acalypha wilkesiana when compared with the controls. The study suggests derangement of liver functions and possible damage to the hepatocytes by the Acalypha wilkesiana at this dose and duration.
Key Words:- Acalypha wilkesiana, Carbon tetrachloride (CCL4), hepatotoxicity, wistar rats. |
Filename | Sule O J et al.-1.pdf |
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Created On: | 01/18/2012 00:00 |
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Last updated on | 03/19/2012 19:20 |
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