Property | Value |
Name | Ascorbic acid supplementation prevents the Adriamycin Induced Genotoxicity in male mice |
Description | Original article:- *Rudrama Devi K, Kusumlatha C, Dilip Reddy K, J. Karuna Kumari and Minny Jael. Human Genetics and Molecular Biology Laboratory, Department of Zoology, Osmania University, Hyderabad-7, India. Abstract:- Background: A number of antineoplatic drugs are used to combat with different types of cancer, and had been shown to cytotoxic. Adriamycin is one of most commonly used in malignant lymphomas. The antioxidants such as VitC inhibits the toxicity of mutagens/carcinogens in animals and Humans. Aim: The protective effects of ascorbic acid in adriamycin induced toxicity in swiss male mice was evaluated using sperm morphology assay. Material and Methods: Two experiments were conducted in germ cells of Swiss male mice. The cauda epidymis was collected from control and exposed group of animals after five weeks of treatment schedule and screened for presence of various types of sperm head abnormalities such as amorphous, banana hammer head etc., Results: The animals treated with 5, 10 and 20 mg/kg of ascorbic acid showed as non mutagenic where as the adriamycin induced significant increase in the percentage sperm head abnormalities but when primed with AA there is decrease in the percentages of abnormal sperms. Conclusion: VitC protects the adriamycin induced genotoxicity in germ cells of mice. Hence VitC supplementation is safer in chemotherapeutic strategy.
Keywords:- Ascorbic acid, genotoxicity, adriamycin, sperm morphology. |
Filename | Rudrama Devi K et al.pdf |
Filesize | 190.08 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 04/17/2012 00:00 |
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Maintained by | Editor |
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Last updated on | 05/24/2012 10:14 |
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