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Name | Comparative antidiarrhoel activity of ethanolic extract of root of Blumea lacera var lacera and Blumea eriantha DC on experimental animals |
Description | Original research article:- *Singh Umesh Pratap 1 and R. Parthasarathy.2 1 Ph.D research scholar- NIMS University Jaipur Rajasthan,India. 2 Director-Faculty of Pharmacy, Kamla Nehru Institute of Management and Technology, Sultanpur, Uttar Pradesh, India.
Abstract:- Roots of Blumea eriantha DC and Blumea lacera have been used in the ayurveda and other folk medicines for the treatment of cholera and diarrhea. To justify its folklore, present study was undertaken to investigate the antidiarrhoel activity of the ethanolic extract from the roots of Blumea eriantha DC (EEBE) and Blumea lacera (EEBL.) Preliminary phytochemical screening, acute toxicity study and antidiarrhoel activity were studied on castor oil induced diarrhea and normal gastrointestinal models of rats at 250, 500 and 750 mg/kg body weight. The preliminary phytochemical screening of the ethanolic extract from the roots of Blumea eriantha DC (EEBE) results with the presence of anthraquinone glycoside, tannins, flavonoids etc.while Blumea lacera showed presence of steroids, terpenoids and alkaloids, flavonoids, saponin and absence of tannin and phnolics, LD50> 1000mg/kg. The doses of EEBE and EEBL both significantly decreased (P<0.001) the total number of diarrheal faeces. PI decreases doses dependently (250, 500 and 750 mg/kg orally) of EEBE and EEBL and was comparable with standard drug atropine sulphate. Conclusively, EEBL has more antidiarrhoel activity in comparison of EEBE but less effective when compared with atropine sulphate in experimental rats.
Keywords:-Blumea eriantha DC (EEBE)., Loperamide, Atropine. Blumea lacera (EEBL) |
Filename | Singh P Umesh et al.pdf |
Filesize | 65.9 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 04/17/2012 00:00 |
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Last updated on | 05/24/2012 16:17 |
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