Property | Value |
Name | ATTENUATION OF POLYCHLORINATED BIPHENYL INDUCED HORMONAL DISRUPTION BY LYCOPENE |
Description | original research article:- *K. Ashok Augustine Raj1, K.Langeswaran2, P. Krishnamoorthy3. 1Assistant Professor in Bioinformatics, 2Assistant Professor in Industrial Biotech, 3Dean-Bioengineering Bharath University, Chennai, TN,India.
Abstract:- The effects of lycopene supplementation on PCB induced endocrine interference caused by PCBs in rat Sertoli cells of PCBs exposed adult rats was investigated. The severity of the endocrine disruption was determined by measuring Traits of reproductive organs; sperm characteristics, testicular histological findings, plasma testosterone levels and the testicular tissue oxidative status were determined. Induction of PCB to rats decreased sperm concentration (p<0.05) and sperm motility (p<0.001), increased total abnormal spermrates (p<0.05) as compared with the control group. An increase in testes malondialdehyde concentrations (p<0.05) and glutathione peroxidase activities (p<0.001) were detected while significant decreases in glutathione levels (p<0.001) in PCB alone group when compared to control group. While pre-treatment with lycopene restoring only malondialdehyde concentrations, its post-treatment caused normalization in both malondialdehyde and glutathione levels when compared with the PCB alone group. On the other hand, significant increases were determined in GSH-Px activities in all experimental groups when compared with the control group. In conclusion, lycopene supplementation was found to be able to diminish the severity of PCB induced endocrine disruption. |
Filename | K Ashok Augustine Raj et al.pdf |
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Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 05/17/2012 00:00 |
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Last updated on | 06/08/2012 13:00 |
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