Property | Value |
Name | Formulation and Evaluation of Multiunit Pellet System of Venlafaxine Hydrochloride |
Description | Research article:- *M. Srujan Kumar1, Binayak Das1, S.V.S.Rama Raju2 1Department of Pharmaceutics, Samskruti college of Pharmacy,Kondapur,R.R District,Hyderabad,India. 2Department of Pharmaceutics, C.L.Baid Metha College of pharmacy, Chennai, India.
Abstract:- Compaction of multiparticulate, commonly called MUPS, is one of the more recent and challenging technologies that combine the advantages of both tablets and pellet-filled capsules in one dosage form. Venlafaxine is an anti depressant, having an elimination half-life of 5±2 hrs and its maximum daily dose is 300mg. Since the drug belongs to BCS class I, it is necessary to retard dissolution to ensure extended release of drug. The objective of the study is to prepare venlafaxine extended release pellets by extrusion spheronization technology, coating them with mixture of rate controlling polymers Ethyl cellulose and different grades of (Hydroxy propyl methyl cellulose (HPMC) using Wurster process to achieve the desired dissolution pattern and compressing the pellets into tablets. The pellets were analyzed for the parameters such as bulk density, tapped density, compressibility index, Hausner’s ratio and the results were found to be within the limits. Drug release rate was more when compared with the innovator sample. The Venlafaxine hydrochloride extended release pellets were compressed into the tablets. The dissolution profile of the prepared Venlafaxine hydrochloride extended release tablets were compared with that of Innovator (VENLAR). Finally conclude like extended release pellets in tablets of formulation (F9) have more drug release rate rather than innovator (VENLAR) and it have better Bioavailability.
Keywords:- Extrusion and Spheronization, HPMC, MUPS, multiparticulate, wurster process. |
Filename | M Srujan Kumar et al.pdf |
Filesize | 389.2 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 05/17/2012 00:00 |
Viewers | Everybody |
Maintained by | Editor |
Hits | 16478 Hits |
Last updated on | 06/08/2012 14:40 |
Homepage | |
CRC Checksum | |
MD5 Checksum |