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Name | RP-HPLC Method for simultaneous estimation of Escitalopram Oxalate and Etizolam in A tablet formulation |
Description | Research article:- *Bhosale Suryakant D.1, Dr. (Mrs.) Rajput Sadhana J.2 1Research Scolar, Quality Assurance Laboratory, Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda. Vadodara-390 001, Gujarat, India. 2Professor, Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda.Vadodara-390 001, Gujarat, India.
Abstract:- RP-HPLC Method For Simultaneous Estimation of Escitalopram Oxalate And Etizolam In A Tablet Formulation. An isocratic reversed phase HPLC method has been developed for the simultaneous determination of escitalopram oxalate and etizolam on a HiQ-silC18HS (250 x 4.6 mm) column using a mobile phase consisting of methanol:phosphate buffer pH-5 (70:30,v/v) at a flow rate of 1 mL/min and the detection was carried out at 254 nm. Retention times of escitalopram oxalate and etizolam were found to be 4.85 (± 0.31) min and 7.65 (± 0.56) min respectively. The method was validated with respect to specificity, linearity, accuracy, precision, ruggedness and robustness. This method is simple, precise, and sensitive and is applicable for simultaneous quantification of escitalopram oxalate and etizolam in a tablet formulation.
Keywords:- Isocratic, reverse phase, validation. |
Filename | Bhosale Suryakant D and Rajput Sadhana J.pdf |
Filesize | 147.68 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 06/18/2012 00:00 |
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Maintained by | Editor |
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Last updated on | 06/25/2012 07:46 |
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