Property | Value |
Name | Activity of Serum Cholinesterase in Organo - Phosphorus poisoning cases: A prospective study |
Description | Original research article:-Biochemistry *Siva Prabodh V1 , Padma Vijaya Sree A2 , Sarma DVHS2 , Siva Reddy M2 1 Dept. of Biochemistry, NRI Medical College and General Hospital, Chinakakani, A.P, India 2 Dept. of Biochemistry, Kurnool Medical College and General Hospital, Kurnool, A.P, India .
Abstract:- Objective: To determine whether serum (pseudo)cholinesterase levels has any diagnostic and prognostic value in acute organophosphorus poisoning. Design: cohort (prospective) study Patients: 40 consecutive patients admitted to ICU for acute organophosphate poisoning. Measurements: Serial measurement of Serum Cholinesterase levels in all patients – 4 times, at the time of admission before administration of PAM(Pyridine aldoxime methiodine), 24hrs after administration of PAM, 48hrs after administration of PAM, 72hrs after administration of PAM. Results: serum cholinesterase levels were significantly decreased in acute organophosphorus poisoning cases when compared to controls and also there is regeneration of serum cholinesterase levels after administration of PAM by 22 %, 45% and 73% after 24hrs, 48hrs and 72 hrs. Conclusion: serum cholinesterase levels have diagnostic value as their levels are significantly decreased in organophosphorus poisoning cases and also prognostic value as there is regeneration of serum cholinesterase levels after administration of PAM.
Key words: -Serum cholinesterase, organo phosphorus poisoning, Pralidoxime, PAM. |
Filename | V Siva Prabodh et al.(N).pdf |
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Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 07/02/2012 10:09 |
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Last updated on | 07/19/2012 09:43 |
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