Property | Value |
Name | Clinical efficacy of subgingivally delivered 0.5% controlled release Azithromycin gel In the management of chronic periodontitis. |
Description | Research article:-Periodontology Vidya Dodwad1, * Shubhra Vaish2, Prashant Tyagi 3 . 1MDS, Professor and HOD,2 MDS,Reader,3 MDS, final year students ,Department of Periodontology, ITS-CDSR, Ghaziabad, India.
Abstract:- Background: Recent developments suggest that the local delivery of antimicrobials into periodontal pockets can improve periodontal health. AZM has a wide antimicrobial spectrum of action towards anaerobic bacteria as well as gram negative bacilli. It is effective against periodontal pathogens like Aggregatibacter Actinomycetemcomitans and Porphyromonas gingivalis. Therefore the present study is as undertaken to investigate the clinical effectiveness of Azithromycin at 0.5% concentration in an indigenously prepared bioabsorbable controlled release gel as an adjunct to non surgical mechanical therapy in the treatment of chronic periodontitis. Method: Thirty sites in patients with chronic periodontitis and probing depth 4-6mm were categorized randomly into two treatment groups: Scaling and Root Planing (SRP) plus 0.5% Azithromycin gel (group 1) and SRP only (group 2). Clinical evaluation was undertaken using the gingival index of Loe and Silness and plaque was assessed using the Turesky et al. modification of Quigley Hein Index at baseline and 21 days. Pocket probing depth and clinical attachment level were also measured using customized acrylic stents. Result: Both therapies resulted in significant improvements. Mean reduction in Gingival Index from baseline to 21 days was 1.20±.41 and .73±.45 in group 1 and group 2 respectively. Plaque Index also improved through the study period in both groups i.e. 0.86±.51 in Group 1 and 1.6±.97 in group 2. Mean probing depth reduced significantly with SRP plus AZM gel application in group 1 i.e. 2.1±.91mm as compared to 1.0±1.06mm achieved with SRP alone. a significant gain in mean CAL gain was observed in the test group (1.8±.63mm) as compared to control group (1.0±1.06mm). Conclusion: Although both treatment strategies seem to benefit patients, the adjunctive use of 0.5% of AZM showed significant results with respect to clinical parameters.
Keywords:-Azithromycin, Local drug delivery, Periodontitis, Scaling and Root planing. |
Filename | Vaish Shubhra et al.pdf |
Filesize | 125.16 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 07/05/2012 00:00 |
Viewers | Everybody |
Maintained by | Editor |
Hits | 5023 Hits |
Last updated on | 07/20/2012 11:09 |
Homepage | |
CRC Checksum | |
MD5 Checksum |