Property | Value |
Name | Antihyperglycemic and antidyslipidemic activity in ethanolic extract of a marine mangrove Xylocarpus granatum |
Description | Research article:- Arvind K. Srivastava*, Savita Srivastava, Swayam Prakash Srivastava, Deepak Raina, Rehan Ahmad, M.N.Srivastava, Ram Raghubir and Vijai Lakshmi. Divisions of Biochemistry, Medicinal and Process Chemistry, Botany and Pharmacology CSIR-Central Drug Research Institute, Lucknow-226001,India.
Abstract: The standardized ethanolic extract of the epicarp of the fruits of a marine mangroove Xylocarpus granatum have been found antihyperglycaemic and antidyslipidemic in nature. The yield of the extract by percolation method at room temperature varies between 8 to 14 % depending upon the season of collection. Studies in normal as well as streptozotocin-induced diabetic rats showed that the extract is effective in the improvement oral glucose tolerance post sucrose load. The extract was also found efficient in declining blood glucose profile of STZ-induced diabetic rats and both glucose as well as cholesterol and triglycerides levels in low dosed streptozotocin- high fructose fed rats and dyslipidemic hamsters. In neonatlly STZ-treated and fructose fed rats, the extract completely controlled their abnormal oral glucose tolerance and improved insulin resistance. The altered biochemical markers i.e. glucose-6-phosphatase, phosphofructokinase, phosphoenolpyruvate carboxykinase, pyruvate kinase, lactate dehydrogenase and glycogen phosphorylase in liver and kidney and except glucose-6-phosphatase, all the other markers in muscles of fructose fed as well as neonatally STZ-treated were also found towards normalization after the oral treatment of CDR-134 D123 at 250 mg/kg dose for three weeks. Controlled clinical trials are going on with this preparation for its usage in the management of type 2 diabetes mellitus.
Key words :-Xylocarpus granatum, Streptozotocin-induced diabetic rats, Neonatally STZ-treated rats, Low dosed STZ treated- high fructose fed rats, Dyslipidemia, hyperglycaemia, hypertriglyceridemia, db/db mice, hamsters, antidiabetic activity, antidyslipidemic activity. |
Filename | Srivastava K Arvind et. al.pdf |
Filesize | 517.88 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 08/17/2011 00:00 |
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Maintained by | Editor |
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Last updated on | 07/20/2012 17:27 |
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