Property | Value |
Name | Is There Thyroid Receptor Resistance In Obesity? |
Description | Original research article:- Medical Bochemistry Kiran Chugh1, Sandeep Goyal2, Vijay shankar1,* Manjulata Kumawat1, S.N. Chugh2, Manjri Goyal2. 1Department of Biochemistry, Pt. B. D. Sharma University of Health Sciences, Rohtak, Haryana, India. 2Department of Medicine, Pt. B. D. Sharma University of Health Sciences, Rohtak, Haryana, India.
Abstract:- Background and Objectives: Metabolic syndrome is the name given to a syndrome that is seen more often in people who are overweight or obese, and who have specific conditions that increase the risk of heart disease, diabetes, stroke, and other health problems. Metabolic syndrome is diagnosed when three out of the following five risk factors are evident. Researchers have now found that even subtle changes in thyroid function increase the risk for metabolic syndrome. We evaluated the thyroid function tests in obesity to explore the possibility of thyroid receptor resistance. Methods: the study was a cross-sectional study. It included 50 obese subjects with Body Mass Index (BMI) > 30 kg/m2 as cases (group I) and 25 individuals with BMI < 25 kg/m2 as controls (group II). T3 (Triiodothyronin), T4 (Thyroxine), TSH (Thyroid stimulating hormone) levels were measured as indicator of thyroid functions. Blood sugar and serum Insulin levels were measured. To define insulin resistance, Homeostasis model for insulin resistance (HOMA IR) was calculated in both groups and the HOMA IR value obtained in group II individuals served as reference mark. Based on the HOMA IR, group I subjects were divided into insulin resistant (subgroup IA) and insulin nonresistant (subgroup IB) individuals. Thyroid function tests were compared in both subgroups. Results: T3 and T4 levels were comparable whereas there was significant difference in TSH levels in insulin resistant (subgroup IA) and insulin nonresistant (subgroup IB) individuals. Conclusion: Raised TSH in insulin resistant obese persons independent of lowered T3 and T4 suggest it to be a part of insulin resistant state in obesity.
Keywords:-Obesity, Body mass index (BMI), Thyroid function tests, Insulin resistance, Homeostasis model assessment for insulin resistance (HOMA IR), Thyroid receptor resistance. |
Filename | Kumawat Manjulata et al.pdf |
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Creator | admin |
Created On: | 08/04/2012 00:00 |
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Last updated on | 07/27/2012 16:32 |
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