Property | Value |
Name | Analysis of lipid profile and 24 hour urinary protein excretion as a predictor of cardiovascular risk in CKD with nephrotic syndrome |
Description | Research article:-Medical biochemistry * Nandedkar Prerna D.1, Kamble Mahendra T.2, Lokhande Suryabhan L.1, Vaidya Seema M.3, Chitta Shrinivas S.4 1M.B.B.S., M.D. (Biochemistry), Assistant professor (Biochemistry), Dept. of Biochemistry, Seth G.S. Medical college and hospital, Parel (E), Mumbai (M.S.),India. 2M.B.B.S., M.D. (Biochemistry), Assistant Professor, Dept. of Biochemistry, Govt. Medical College & Cancer Hospital, Aurangabad (M.S.),India. 3 M.Sc.(Biochemistry), PhD., Professor, Dept. of Biochemistry, Government Medical college, Latur, (M.S.),India. 4 M.B.B.S, M.D. (Physiology), Junior resident, Dept. of Physiology, Government Medical college, Nagpur, (M.S.), India.
Abstract:- Background: Patients with chronic kidney disease (CKD) have a higher prevalence of dyslipidemias than the general population. Almost all patients of CKD with nephrotic syndrome have an abnormal lipid profile and the cause of death in most of patients is cardiovascular complications. This dyslipidemia may be correlated with proteinuria. Therefore, it is important to screen all patients of CKD with nephrotic syndrome for dyslipidemia and find out its correlation with proteinuria. Aim:To estimate lipid profile and 24 hour urinary protein in patients of CKD with nephrotic syndrome. Settings and designs: This cross sectional study was undertaken in the Department of Biochemistry and Department of Medicine of Government Medical College and hospital Nagpur, Maharashtra. Material and method and statistical analysis: lipid profile and 24 hour urinary protein excretion were analyzed and compared between 50 age & sex matched CKD with nephrotic syndrome cases and CKD without nephrotic syndrome controls of age group 25‐60 years using unpaired two‐tailed Student‘t’ test. Results:Values of total cholesterol (p<0.001), triglyceride (p<0.001), LDL-C (p<0.001) and 24 hour proteinuria (p<0.001) were significantly higher in CKD with nephrotic syndrome compared to CKD without nephrotic syndrome but values of HDL-C (p<0.001) were significantly lower compared to CKD without nephrotic syndrome. Conclusion: Cardiovascular complications can be more frequent in patients of CKD with nephrotic syndrome and dyslipidemia correlates directly with severity of 24 hour proteinuria.
Keywords:- (CKD) chronic kidney disease, (NS) nephrotic syndrome, 24 hour proteinuria, Dyslipidemia,(CVD) cardiovascular disease. |
Filename | Prerna Nandedkar et al.pdf |
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Creator | admin |
Created On: | 08/04/2012 00:00 |
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Last updated on | 07/27/2012 16:31 |
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