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Name | Microwave and Conventional Synthesis of Pyrimidine Derivatives and their Pharmacological Activity- A Review |
Description | Review article:-Engineering chemistry *Chandak Shilpa1, Sharma Dipak2, Sharma Vimukta3 and Dubey Arti. 1Department of Engineering Chemistry, VITS, Indore, MP, India. 2Department of Chemical Sciences, Maharaja Ranjit Singh College of Professional Sciences,Indore, MP, India. 3Principal, B.M. College of Pharmacy, Indore, MP, India.
Abstract:- Pyrimidines have been reported to possess various biological activities. Review indicates that compounds having pyrimidine nucleus have wide range of therapeutic uses that includes antimicrobial, antiviral, antioxidant, antitumer, antilukemia, antileishmanial and anti-inflammatory. Due to interesting activity of various substituted pyrimidines as biological agents considerable attentions have focused on this class. The pharmaceutical importance of these compounds lies in the fact that they can be effectively used as analgesics, anti-inflammatory, anticonvulsant, insecticidal, herbicidal, antitubercular anticancer and antidiabetic agents. The ability of thiazine to exhibit antitubercular, antibacterial which is inactivate HIV in biological fluids and used as cannabinoid receptor agonists. In the light of these interesting biological activities, it appeared of interest to synthesize some new pyrimidine derivatives. Pyrimidine is the most important member of all the diazines as this ring system occurs widely in living organisms. Purines, uric acid, alloxan, barbituric acid and a number of antimalarial and antibacterial drugs also contain the pyrimidine ring. Various derivatives like 4-(Morpholin-4-yl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine(1), 4-(3-Methyl-5-phenyl-1H-pyrazol-1-yl)-5, 6, 7, 8-tetrahydro [1] benzothieno [2, 3-d] pyrimidine(9), 4-Benzoyl-3-(4-fluorophenyl)-1-(4-nitrophenyl)-5-phenylpyrazole (11). -been thoroughly studied and it was found that they are synthesized by conventional method of synthesis with different solvents and conditions similarly while1-Methyl-2-methylthio-4-(anisyl)-5-cyano-1,6-dihydropyrimidine-6-one.(24), 5-Cyano-1-(2,4-dimethyl-phenyl)-6-(4-methoxyphenyl)-2-thiouracil(40) were studied and they were found to have an advantage over the conventional once as their method was by microwave synthesis. Furthermore all these compound posses’ good pharmacological activities. Hence the review of pyrimidine derivatives gives a vast scope for further research in this area.
Key Words:- Pyrimidine derivatives, pharmacological activities, conventional method and microwave synthesis, benzothieno, antimicrobial activity, heterocyclic compound. |
Filename | Chandak Shilpa et al.pdf |
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Created On: | 08/04/2012 08:20 |
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