Property | Value |
Name | Effect of Gongronema latifolium leaf extract on some Kidney enzymes and protein levels in Diabetic and non Diabetic rats |
Description | Research article:-Biochemeistry E.E.Edet1,*F.E. Uboh1, T. E. Edet2,3, I. J. Atangwho1, E. David-Oku1. *1 Department of Biochemistry University of Calabar, P.M.B. 1115, Calabar, Nigeria. 2 Department of Fisheries, Ministry of Agriculture, Cross River State, Nigeria.
Abstract:- The effect of leaf extract of Gongronema latifolium (GL) on some kidney tissue enzymes and total protein levels of alloxan-induced diabetic rats was studied. Graded doses of the extract (200, 300 and 400 mg/kg b.wt) were administered to diabetic and non-diabetic rats for 14 days. On the 15th day, the animals were sacrificed and the total protein, aminotransferases (ALT and AST), alkaline phosphatase (ALP) and gamma glutamyl transpeptidase (GGT) assayed in the kidney tissue whole homogenate (KWH). The result showed a significant (p<0.05) decrease in total protein concentration, and increase in ALT, AST, ALP and GGT activities in non-treated diabetic rats when compared to the non-treated non-diabetic control rats. Treatment of non-diabetic rats with GL produced a dose-dependent non-significant (p>0.05) increase in total protein, ALT, AST, ALP and GGT, compared to the non-treated non-diabetic rats. However, total protein concentrations in diabetic rats, treated with 200, 300 and 400 mg/kg b.wt of GL were significantly (p<0.05) increased, while AST, ALT, ALP and GGT activities decreased, in a dose-dependent pattern when compared to the non-treated diabetic rats. These results indicate that oral treatment with GL may be used to alleviate the kidney functions impairment associated with diabetic condition.
Keywords:- Alloxan, Diabetes, kidney enzymes, kidney proteins, kidney function. |
Filename | Uhoh F.E et al.pdf |
Filesize | 126.51 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 08/18/2012 00:00 |
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Maintained by | Editor |
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Last updated on | 08/20/2012 05:00 |
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