Property | Value |
Name | Prognostic significance of Apolipoprotein B over traditional lipid parameters in atherosclerosis risk management in Type 2 diabetes mellitus. |
Description | Research article:-Biochemistry 1*Dr. Lokhande Suryabhan L, 2 Dr. Iyer Chandrashekhar M, 3 Dr. Shinde Ratnendra R, 4 Dr. Nandedkar Prerna D, 5 Dr. Kamble Mahendra T. 1*MD Biochemistry; Assistant professor, Department of Biochemistry Government Medical College Nagpur, India. 2MD Biochemistry; Professor, Department of Biochemistry,Government Medical College Nagpur, India. 3M.D. Preventive and Social Medicine; Professor and Head, Department of Preventive and Social Medicine, Seth G.S. Medical College and Hospital Mumbai, India. 4,5MD Biochemistry; Assistant professor, Department of Biochemistry Government Medical College Nagpur, India.
Abstract:- Background and Objectives: Type 2 Diabetes Mellitus (Type 2 DM) characterised by relative insulin deficiency or insulin resistance is associated with glucose intolerance, hypertension, a unique dyslipidemia, a procoagulant state, and an increase in macrovascular disease. The present study was conducted to assess the significance of Apolipoprotein B in cardiovascular diseases (CVD) and complications. Materials and Methods and Statistical Analysis: 50 diagnosed cases of type 2 DM in the age group 35-65 years were included in the study and 50 age and sex matched healthy controls were taken as controls. In both the groups, we have measured serum levels of traditional lipid parameters comprising of total cholesterol (TC), triglyceride (TG), HDL-C, low density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo-B) and waist-hip ratio (WHR) as cardiovascular risk factors. Statistical analysis was done by students unpaired‘t’-test and linear regression analysis and correlation. Results: The results of this study shows significant increased level of serum total cholesterol, TG, LDL-C and VLDL-C and Apo-B in type 2 DM patients as compared to controls (p<0.001). While Serum HDL-C level was significantly lower in type 2 DM patients as compared to controls (p<0.001). The waist hip ratio of Type 2 DM patients was found to be significantly higher as compared to controls. Conclusion: The findings of the present study indicated that apolipoprotein B (Apo-B) as a cardiovascular risk factors are significantly elevated in type 2 DM patients as compared to controls and apolipoprotein B (Apo-B) significantly elevated even if lipid profile parameters such as LDL-C and HDL-C were found to be normal, signifying routine estimation of apolipoprotein B (Apo-B), in addition to traditional lipid parameters in the cardiovascular risk assessment in Type 2 Diabetes Mellitus. Key Words:- Type 2 Diabetes Mellitus (Type 2 DM), Apolipoprotein B (Apo-B), Traditional lipid parameters, Cardiovascular disease (CVD), Waist-hip ratio (WHR). |
Filename | Lokhande Suryabhan L. et al.pdf |
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Creator | admin |
Created On: | 08/09/2012 00:00 |
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Last updated on | 08/20/2012 15:32 |
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