Property | Value |
Name | Prostate specific antigen: a post natal growth factor? |
Description | Research article:-Biochemistry *Renu Nagar Department of Biochemistry, Dr. RP Govt. Medical College, Kangra, Himachal Pradesh, India. Abstract:-Prostate Specific Antigen (PSA) has long been used as a biological marker for prostatic cancer. Recent studies have demonstrated that PSA synthesis can be induced in both sexes by steroid hormones including Progesterone. PSA is present in the breast milk and other body fluids and tissues of women in health and in various disease conditions. The massive amounts of steroid hormones produced by the placenta during pregnancy stimulate PSA synthesis in the breast tissue. PSA in breast milk probably plays an important role in post-natal growth and development of the infant by virtue of its IGFBP 3 protease activity liberating IGF-I, its very cationic nature, the inactivation of the Protein C inhibitors and extensive homology of PSA with Tissue kallikrein, gamma Nerve growth factor and Epidermal growth factor binding protein. In this study, PSA levels in breast milk were found to decrease with increasing time post-partum. The milk PSA levels were higher in case of lesser gestation at delivery, smaller birth weight of the baby and for a male baby.
Key Words:-Prostate Specific Antigen, PSA, Serine protease, Kallikrein, Breast milk, Insulin like growth factor binding protein, Insulin like growth factor. |
Filename | Nagar R.pdf |
Filesize | 158.23 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 09/03/2012 13:08 |
Viewers | Everybody |
Maintained by | Editor |
Hits | 4194 Hits |
Last updated on | 09/03/2012 13:14 |
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