Property | Value |
Name | Microbiological Evaluation of Antibiotic Resistance in Bacterial Flora from Skin Wounds |
Description | Original article:-Medical microbiology *Adenike A.O. Ogunshe,1 Mary T. Niemogha,2 Gabriel N. Azum3 & Anthony N. Odikagbue4 2 Nigerian Institute of Medical Research, 6 Edmond Crescent, PMB 2013. Yaba, Lagos, Nigeria. 3Department of Botany & Microbiology, Faculty of Science, University of Ibadan, Nigeria. 4Department of Medical Microbiology & Parasitology, University College Hospital, Ibadan,Nigeria.
Abstract:- Phenotypic antibiotic resistance profiles of 172 human wound-borne bacterial strains of (Bacillus, Staphylococcus, Streptococcus, Clostridium, Aeromonas, Enterobacter, E. coli, Klebsiella, Morganella, Proteus, Pseudomonas, Shigella and Yersinia) species, isolated from ≤ 75-year female and ≤ 85-year old male patients, including neonates and children, at two General hospitals and two tertiary health care institutions in Lagos and Oyo States of Nigeria were determined. High resistance and multiple antibiotic resistance (MAR)- Lagos: (Gram-positive = 62.3-100%; MAR = 25.0-100% / Gram-negative = 75.0-100%; MAR = 50.0-100%) and Ibadan: (Gram-positive = 57.9-97.4%; MAR = 40.0-100% / Gram-negative = 51.0-93.9%; MAR = 50.0-100%) against antibiotics (discs) were exhibited by the bacteria respectively. Gram-positive bacteria from Lagos were totally resistant to cloxacillin, while Gram-negative bacteria were totally resistant to cotrimoxazole but strains from Ibadan were mostly resistant to gentamicin / tetracycline (81.6%), erythromycin (89.5%), cloxacillin (97.4%) and augmentin (93.9%). Overall susceptibility rates to antibiotic drugs commonly used in self-medication for topical and systemic wound treatments in Nigeria were- penicillin, ampicillin (73.9%), erythrocin, tetracycline (78.3%) and erythromycin (82.6%). In conclusion, relatively high resistance and MAR to antibiotic discs but very high susceptibility to certain antibiotic drugs were exhibited by wound-borne bacteria, indicating that potent antibiotic drugs can serve as topical therapeutic agents in skin wound treatment.
Key Words- Antibiotics, septic wounds, topical skin treatments, wound cultures, wound care. |
Filename | Adenike A.O..pdf |
Filesize | 1.11 MB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 09/04/2012 03:35 |
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Last updated on | 09/05/2013 11:09 |
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