Property | Value |
Name | Evaluation of iron oxide nanoparticles effects on tissue and enzymes of liver in rats |
Description | Research article:-Biology 1Vahid Yousefi Babadi, *2Leila Najafi , 3Azadeh Najafi, 4Hosein Gholami, 5Mohammad Ebrahim Beigi Zarji, 6Jalal Golzadeh, ,7Esmaiel Amraie,8Ali Shirband.
1,5,7,8M.A.in Biology,Payam-e-Noor University of Tehran,Tehran,Iran. 2Ph.D.Candidate in Health Care Services Administration, Shahid Beheshti University of Medical Sciences,Tehran,Iran. 3M.A. in Sociology,Research and sciences Branch Islamic Azad University,Tehran,Iran. 4G.P.Shahid Beheshti University of Medical Sciences,Tehran,Iran. 6M.A.in Biology,Uromieh University,Uromieh,Iran..
Abstract:- Background: Iron oxide nanoparticles can be used for medical imaging,disease diagnosis,drug delivery,cancer treatment,gene therapy and other cases.These particles accumulate in liver cells and lead to oxidative stress with generation of reactive oxygen species. Objectives: This study investigates the effect of iron oxide nanoparticles on liver tissue and enzymes[alanine aminotransfere(ALT),aspartate aminotransferase(AST)and alkaline phosphatase(ALP)]in male rat. Materials and methods: 40 adult male rats of wistar strain, weighing 250-300g were used for this study.The ratswere randomly assigned to four groups.One group was control and other three groups were fed with iron oxide nanoparticles at 20, 50 and 150 µg/kg concentrations respectively for 15 days. Venous blood was taken to measure liver enzymes at the end of treatment. Liver of rats removed for histological experiments. Results: Significantly enhanced (P<0.05) AST level obtained as well as ALT and ALP level with used of maximum concentration of iron oxide nanoparticles (150 µg/kg) as compared to normal group. Conclusion: Based on our result, using high concentration of iron oxide nanoparticles could be caused undesirable effects on liver with damage to hepatocyte and level elevation of liver enzymes.
Key words:- Hepatocyte, Nanoparticle, Enzyme, Iron oxide. |
Filename | Najafi Leila et al.pdf |
Filesize | 1.91 MB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 10/04/2012 00:00 |
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Maintained by | Editor |
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Last updated on | 10/10/2012 08:16 |
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