Property | Value |
Name | Serine proteases and their roles in disorders of nervous system |
Description | Review article:-Pharmacology Manoj G Tyagi and K Arumugasamy Department of Pharmacology, Christian Medical College, Vellore 632002, Tamilnadu, India.
Abstract:-Serine protease inhibitors contribute in patho-physiological conditions.An important Serine protease enzyme inhibitor like the Protease nexin-1 (PN-1) is a 43 kDa protein of the serpin superfamily secreted in the extracellular space, where it binds and inhibits several serine proteases, including thrombin, trypsin, plasmin, tPA, and uPA. Its expression is finely regulated both spatially and temporally during development and in adulthood. In vivo, PN-1 regulates proteolytic activity in both the central nervous system (CNS) and peripheral nervous system (PNS). Mechanistically, PN-1 has been shown to promote neurite outgrowth and regulate survival or death of injured neurons. Injury of the rat sciatic nerve triggers PN-1 production in Schwann cells localized at the distal site of the lesion, possibly to protect structures from prolonged and extensive proteolytic attacks.This review reflects on their roles in nervous system disorders.
Key Words:- Protease inhibitor, Protease nexin-1, nerve, skeletal, thrombin. |
Filename | Tyagi G Manoj and Arumugasamy K.pdf |
Filesize | 155.4 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 10/04/2012 00:00 |
Viewers | Everybody |
Maintained by | Editor |
Hits | 3085 Hits |
Last updated on | 10/12/2012 17:25 |
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