Property | Value |
Name | Presence of metalloestrogens in ectopic endometrial tissue |
Description | Research article:- Physiology Nalinda Silva, MBBS1*, Hemantha Senanayake, FRCOG2, Roshini Peiris-John, Ph.D 3, Rajitha Wickremasinghe, Ph.D4, Nalini Sathiakumar, Dr.PH5 and Vajira Waduge, M.Sc.6 1Lecturer in Physiology,Faculty of Medical Sciences University of Sri Jayewardenepura, Sri Lanka. 2Professor in Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Colombo, Sri Lanka. 3Visiting academic, Section of Epidemiology and Biostatistics, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, New Zealand. 4Dean and Professor of Public Health,Faculty of Medicine, University of Kelaniya, Sri Lanka 5Professor of Public Health, University of Alabama at Birmingham, United States. 6Senior Scientific Officer, Life Sciences Division, Atomic Energy Authority, Colombo, Sri Lanka.
Abstract: Background: Heavy metals with estrogenic effects are termed as metalloestrogens which are implicated in the etiology of endometriosis; an estrogen dependent disease. Aim: To demonstrate the presence of metalloestrogens in ectopic endometrial tissue. Settings: A gynaecology unit of a tertiary care hospital and two national level laboratories. Design: Descriptive study Methods: In fifty patients with endometriosis confirmed by laparoscopy or laparotomy, ectopic endometrial tissue samples (n=50) were collected. Tissue samples were digested using supra pure 65% HNO3 and levels of metalloestrogens were measured using Total Reflection X-ray Fluorescence (TXRF) and graphite furnace atomic absorption spectroscopy (GFASS). Results: Three metalloestrogens, namely cadmium, nickel and lead were detected in the ectopic endometrial tissue with geometric mean (95% CI) levels of 2.861 (2.126-3.596), 17.547(13.152-21.942) and 25.785(18.490-33.080) μg/Kg respectively. Conclusion: In this study, metalloestrogens viz. cadmium, nickel and lead were present in the ectopic endometrial tissue.
Key words: Cadmium, ectopic endometrial tissue, endometriosis, metalloestrogens, nickel. |
Filename | Silva Nalinda et al.(1-5).pdf |
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Created On: | 11/04/2012 00:00 |
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Last updated on | 11/21/2012 15:11 |
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