Property | Value |
Name | Bacterial Isolates from Sputum of HIV Seropositive Patients |
Description | Research article:-Microbiology M.Bharathi M.D1* and A.Usha Rani M.D2 1*Assistant Professor, Department of Microbiology, Andhra Medical College, Visakhapatnam, India. 2Professor, Department of Microbiology, Siddartha Medical College, Vijayawada, India.
Abstract:- Background:- HIV infection is presently accounts for the highest number of deaths attributable to any single infective agent. Opportunistic infections (OIs) account for a considerable proportion of such mortality. Among OIs, respiratory tract infections are one. Preventable and treatable respiratory infections are seen in up to two thirds of all HIV positive persons. Aim: - To know the bacterial pathogens other than M .tuberculosis that cause lower respiratory tract infections and their susceptibility pattern in HIV seropositive patients. Material and methods: - 100 HIV seropositive patients attended to ART centre comprised the study group. Deep, coughed up sputum was collected from patients after taking informed, written consent. After assessing quality of sputum by doing Gram’s stain, sample was inoculated on Blood agar, Mac Conkey agar and Chacolate agar. Pathogens were identified by standard methods. Results:- 59 samples were culture positive. single pathogen was isolated in 33 cases and polymicrobial in 26 cases, with total 89 pathogens. The organisms isolated were S.pneumoniae, S.aureus, β haemolytic Streptococci, Nocardia asteroides, Klebsiella pneumoniae, Esch.coli, Pseudomonas aeruginosa, Acinetobacter boumannii, and Serratia marcescens. Most of the strains were susceptible to amikacin, ciprofloxacin, cefotaxim, amoxyclav, doxycyclin and roxythromycin. 17 patients had CD4 counts of <200 with culture positivity in 14 cases (82.35%) and polymicrobial etiology in 35.29% cases. CD4 counts of 201-500 were found in 53 patients with 58.49% culture positivity and 26.41% polymicrobial etiology. 30 had counts of >500 with culture positivity in 14 cases (46.46%) and polymicrobial etiology in 20% cases. Conclusions: - S.pneumoniae was the commonest pathogen (38.2%). Polymicrobial etiology of respiratory tract infections was observed in all strata of CD4 counts, but at higher frequency as CD4 count decreases.
Key words:- HIV seropositive patients, CD4 count, Lower respiratory tract infections, Bacterial pathogens. |
Filename | M.Bharathi and A.Usha Rani.(92-96).pdf |
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Creator | admin |
Created On: | 11/04/2012 00:00 |
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Last updated on | 11/27/2012 05:52 |
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