Property | Value |
Name | Formulation development and evaluation of hydrodynamically balanced system of Verapamil hydrochloride |
Description | Research article:-Pharmaceutics. Shinde Shivram B*., Shahi Sadhana R., Lone Vidya R., Jumbade Pooja P. Department of Pharmaceutics, Goverment College of Pharmacy, Aurangabad-431005. Maharashtra, India.
Abstract:- The purpose of this research was to develop the hydrodynamically balanced (HBS) delivery system of Verapamil Hydrochloride which, after oral administration should have the ability to prolong gastric residence time with the desired in vitro release profile for the systemic action in the treatment of hypertension. A 32 full factorial design was employed to optimize the formulation wherein hydroxypropylmethylcellulose K4M (HPMC K4M) (X1) and Carbopol 934 (X2) were taken as independent variables and amount of drug release after 12 h (Y1) was taken as the dependent variable. The capsules were prepared by physical blending of Verapamil Hydrochloride and the polymers in varying ratios. The formulation was optimized on the basis of in vitro buoyancy and in vitro release. The release data were evaluated by model depended (curve fitting method) using PCP Disso v2.08 software. Optimization studies were carried out using the Design Expert Software 8.0.1. Formulations were evaluated for in vitro buoyancy and in vitro release studies. The in vitro release followed zero order kinetics and drug release mechanism was found to be Case-II transport. It was found that both HPMC and Carbopol and their interaction had significant impact on the release and floating properties of the delivery system. Thus, combination of HPMC K4M and Carbopol 934 can be used to increase the gastric residence time and drug release for a period of 12 h.
Key words:- Hydrodynamically balanced system, Verapamil Hydrochloride, HPMC K4M, Carbopol, Factorial design. |
Filename | Shinde et al.(125-129).pdf |
Filesize | 575.21 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 12/03/2012 08:18 |
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Maintained by | Editor |
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Last updated on | 12/03/2012 08:22 |
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