Property | Value |
Name | High Prevalence of Multi-Drug resistant Citrobacter spp. from tertiary care hospital, pimpri, Pune, India |
Description | Research article:-Microbiology Rabindranath Misra,Nageswari Gandham, Moumita Sardar, Mahadev Ujagare, Kalpana Angadi, Chanda Vyawahare, Indranath Roy and Savita Jadhav* Department of Microbiology,Pad. Dr. D.Y. Patil medical college and Hospital, Pimpri Pune-411018, Maharashtra, India.
Abstract:- Introduction: Citrobacter freundii is an opportunistic pathogen that can cause diarrhoea, urinary tract infection, respiratory tract infection and acute meningitis. In health care settings Citrobacter species have become an increasing cause of concern as they are multi-drug resistant (MDR) and associated with high mortality between 30-60%. Recently, there has been an increase in isolates of Citrobacter species from various clinical specimens from different patients in our hospital. We investigated the epidemiology of Citrobacter species in patients admitted in our hospital and noted down the antibiotic susceptibility pattern and framed antibiotic policy for the treatment of multi-drug resistant Citrobacter. Materials & Methods: Study was conducted in Pad. Dr. D.Y. Patil Medical College, Hospital and Research Center, Pune from 1st Jan to 31st July 2011. Specimens were collected and implicated pathogens were identified by standard conventional methods. Susceptibility testing was performed according to Clinical and Laboratory Standards Institute (CLSI) guidelines. Result & Observations: The results showed high isolation of Citrobacter spp. Total 114 Citrobacter spp. were isolated and from various samples.vis body fluid 29 (25.43%), urine 26 (22.80%), blood 23 (20.17%), pus 23(20.175).Maximum isolates were from medicine ward and MICU 40(35.81%) and21(20.18%) respectively. Out of 114 Citrobacter spp. 51(44.73%) were ESBL producers and 12 (10.52%) MBL producers. Total 63 (52.26%) strains were MDR. As against this during the same period in previous year total 32 Citrobacter spp were isolated of which 4 were MDR. Conclusion: We report high prevalence of MDR Citrobacter species as a nosocomial pathogen in our hospital and thus recommend revising the treatment protocol. In the present scenario, where ESBL genes are predominant in Citrobacter, Cefoperazone/ceftazidime and Tazobactum combination are ideal choice instead of carbapenems. Carbapenems should be kept as a reserve drug. This bacterium shows rising resistance to these drugs; hence indiscriminate use of antibiotics should be avoided.
Key words:- Citrobacter frundii, Citrobacter koserii, Multidrug resistance, Nosocomial infections. |
Filename | Jadhav Savita et al.(158-163).pdf |
Filesize | 379.84 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 12/03/2012 00:00 |
Viewers | Everybody |
Maintained by | Editor |
Hits | 3008 Hits |
Last updated on | 12/07/2012 11:38 |
Homepage | |
CRC Checksum | |
MD5 Checksum |