Property | Value |
Name | Effect of vetiveria zizanioides on experimentally induced depression in albino rats |
Description | Research article:- Pharmacology Glory Josephine.I1*, Arul Amutha Elizabeth2, Farhana Rahman3, InbarajS.D4, Muniappan.M5, Muthiah6. 1,2,4Associate Professor,3Assistant professor,4,5Department of Pharmacology, Sree Balaji Medical college, Chrompet,Chennai,India.
Abstract:- Aim: Depression is a severe psychiatric disorder with a lifetime prevalence as high as 21%. In Ayurveda ,the a ancient traditional system of medicine, mention a number of single and compound drug formulation of plant origin that have been used to treat the psychiatric disorders. Vetiveria zizanioides is the common source of the well known oil of vetiver, particularly used in aromatherapy and regarded as a tonic to the nervous system.So our aim is to compare the effects of the antidepressant drug fluoxetine and vetiveria zizanioides on depressive behavior in albino rats. Materials and methods: Both Forced swimming test(FST) and Tail suspension test(TST) were used for screening antidepressant effect, The ethanolic extract of Vetiveria zizanioides at three different doses (50,100,200mg/kg,i.p.), fluoxetine(10mg/kg) and saline were administered 30mts prior to the tests and the immobility period was recorded for 6mts.The antidepressant effect of Vetiveria ziizanioides was compared to that of fluoxetine. Results: Both fluoxetine(10mg/kg) and Vetiveria zizanioides (100mg/kg) produced significant antidepressant effect by reduction in immobility period as compared to control. However findings suggested that combination of fluoxetine and Vetiveria is more effective than Vetiveria alone Conclusion: The results of the present study indicated the antidepressant activity of Vetiveria zizanioides and potential for use of an adjuvant in depression.
Keywords:- Antidepressant, Forced swimming test, Tail suspension test, Vetiveria zizanioides. |
Filename | Glory Josephine. I et al.(171-175).pdf |
Filesize | 385.28 kB |
Filetype | pdf (Mime Type: application/pdf) |
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Created On: | 12/03/2012 00:00 |
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Last updated on | 12/10/2012 11:26 |
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