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Details for Comparison of efficacy of Esmolol and Lignocaine in attenuating cardiovascular response during laryngoscopy and intubation
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NameComparison of efficacy of Esmolol and Lignocaine in attenuating cardiovascular response during laryngoscopy and intubation
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Research article:-

Saravanan D1*, Ranganathan.S1, Harikumar.S1 & Sumathi.K2.

1Department of Anaesthesia,2Department of Biochemistry, Shree Balaji Medical College and Hospital, Chennai (Bharath University).

 

Abstract:- Background: Esmolol and Lignocaine attenuates cardiovascular response during laryngoscopy and intubation. The aim of the study is to compare Lignocaine versus Esmolol to observe the effect on cardiovascular response to laryngoscopy and endotracheal intubation. Materials and Methods: Fifty elective surgical patients of active age group (16 -60 years) American Society of Anesthesiologist physical status I & II irrespective of surgical procedure were randomly assigned to one of the two groups (A and B). Group A received injection Esmolol 0.5mg/kg injected slowly over a period of 2 minutes followed by maintenance injection 0.2mg/kg/min till intubation was completed. Patients in group B received injection Lignocaine 1 mg/kg injected slowly over a period of 2 minutes followed by maintenance injection 0.4mg/kg/ min till intubation was completed. Hemodynamic parameter i.e. blood pressures (systolic blood pressure, diastolic blood pressure and mean blood pressure), heart rate, rate were monitored after bolus, after administration of induction agents, after intubation, and at 2minutes and 10 minutes after intubation. Results: There were statistically significant (p<0.001) fall in blood pressures, heart rate and in group A i.e. pretreatment with intravenous Esmolol and remained so after 10 minutes. On the other hand there were no statistically significant (p>0.01)fall in heart rate, blood pressures and rate pressure product in group B, where pretreatment done with Lignocaine. Conclusion: The study showed that pretreatment with Esmolol 0.5mg/kg injected slowly over a period of 2 minutes followed by maintenance injection 0.2mg/kg/min till intubation suppresses the cardiovascular response due to laryngoscopy and intubation.

 

Key words:- Cardiovascular response, laryngoscopy, Esmolol, Lignocaine.

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