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Name | Role of biochemistry in depression |
Description | Review article:- Biochemistry Ranganathan Lakshmi 1* &. Swaminathan S2. *1Research Intern Krishnamacharya Yoga Mandiram, New No. 31, Old No. 13, 4th Cross Street, R K Nagar, Mandaveli, Chennai, Tamil Nadu 600028, India. 2Chief of Biochemistry, SRM Institute of Medical Sciences No: 1, Jawaharlal Nehru Salai, (100 feet Road), Vadapalni Chennai – 600 026, India.
Abstract:- Depression is a multi-dimensional disorder. It is neither purely a biochemical, nor a psychological phenomenon. Biological factors, genetic factors, personality traits and life events may all contribute to depression. Depression has biological components based in genetics, neurochemistry and physical health; it has psychological components that involve many individual factors such as cognitive style, coping style, and qualities of personal behaviour. And, it has social components, factors that are mediated by the quality of one’s relationships, including such variables as the family and the culture one is socialized into, and one’s range of social skills. Beyond all existing theories of depression, the greatest areas of agreement about depression are 1. The condition is complex (heterogeneous) 2. There is no ‘one’ explanation of its cause 3. There has been no single treatment known that will be effective in all cases. Several studies have proved that biochemical changes occur in depression and that these can be prompted or further modified by psychosocial factors. The balance of such factors in an individual may provide the clues to successful management with a combination of drugs and psychosocial therapy. This review article on the role of Biochemistry in depression in humans will enable researchers to understand in detail, the works already done and will give awareness about further works to be carried out in this field. Almost all biochemical disorders related to depression have been covered in this paper. This paper highlights the role of various biochemical analytes in inducing /reversing the symptoms of depression. Only key biochemical analytes are considered. Key words:- Depression, Vitamin, CVD, ANS, WBC, CRP,HbA1C,Renal Profile, TSH, Cortisol, LH, FSH,PCOS, Acetyl choline, Endorphins, Prolactin, Oxidative Stress. References:- 1.Stumpf, W. E., Privette, T. H. “Light, vitamin D and psychiatry”. Role of 1,25 dihydroxyvitamin D3 (soltriol) in etiology and therapy of seasonal affective disorder and other mental processes. Psychopharmacology (Berl.) 1989; 97:285-94. 2.Gloth, F. M., 3rd, Alam, W., Hollis, B. “Vitamin D vs. broad spectrum phototherapy in the treatment of seasonal affective disorder.” J. Nutr. Health Aging .1999; 3:5-7. 3.Vieth, R., Kimball, S., Hu, A., Walfish, P. G. “Randomized comparison of the effects of the vitamin D3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the well being of patients”. Nutr. J. 2004; 3: 8. 4.Lansdowne, A. T., Provost, S. C. “Vitamin D3 enhances mood in healthy subjects during winter”. Psychopharmacology (Berl.).1998; 135:319-23. 5.Dumville, J. C., Miles, J. N., Porthouse, J., Cockayne, S., Saxon, L., King, C. “Can vitamin D supplementation prevent winter-time blues? A randomised trial among older women”. J. Nutr. Health Aging .2006: 10:151-3. 6.Kenny, A. M., Biskup, B., Robbins, B., Marcella, G., Burleson, J. A. “Effects of vitamin D supplementation on strength, physical function, and health perception in older, community-dwelling men”. J. Am. Geriatr. Soc. 2003; 51,1762-7. 7.Willem J. Kop, PhD, Phyllis K. Stein, PhD, Russell P. Tracy, PhD, Joshua I. Barzilay, MD, Richard Schulz, PhD, and John S. Gottdiener, MD. “Autonomic Nervous System Dysfunction and Inflammation Contribute to the Increased Cardiovascular Mortality Risk Associated With Depression”. Psychosom Med. 2010 September; 72(7): 626–35. 8.Chavda N, Kantharia ND, Jaykaran. “Effects of fluoxetine and escitalopram on C-reactive protein in patients of depression”. J Pharmacol Pharmacother. 2011 Jan;2(1):11-6. 9.Bornivelli C, Aperis G, Giannikouris I, Paliouras C, Alivanis P. “Relationship between depression, clinical and biochemical parameters in patients undergoing haemodialysis”. J Ren Care. 2012 Jun;38(2):93-7. 10.Kontoangelos K, Raptis AE, Papageorgiou CC, Papadimitriou GN, Rabavilas AD, Dimitriadis G, Raptis SA. “The association of the metabolic profile in diabetes mellitus type 2 patients with obsessive-compulsive symptomatology and depressive symptomatology: New insights”. Int J Psychiatry Clin Pract. 2012 Aug 6. 11.Osvaldo P Almeida, Paul E Norman, Richard Allcock, Frank van Bockxmeer, Graeme J Hankey, Konrad Jamrozik and Leon Flicker. “Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: The Health in Men Study”. Int. J. Epidemiol. 2009; 38 (4): 1049-59. 12.Daniel E. Ford, MD, MPH; Thomas P. Erlinger, MD, MPH. “Depression and C-Reactive Protein in US Adults”. Arch Intern Med. 2004; 164:1010-14. 13.Rabe-Jabłońska J, Poprawska I. “Levels of serum total cholesterol and LDL-cholesterol in patients with major depression in acute period and remission”. Med Sci Monit. 2000 May-Jun;6(3):539-47. 14.Partonen T, Haukka J, Virtamo J, Taylor PR, Lönnqvist J. “Association of low serum total cholesterol with major depression and suicide”. Br J Psychiatry. 1999 Sep;175:259-62. 15.Giovanni Cizza, Vi T. Nguyen, Farideh Eskandari, Zhigang Duan, Elizabeth C. Wright, James C. Reynolds, Rexford S. Ahima, and Marc R. Blackmang. “Low 24-hour adiponectin and high nocturnal leptin concentrations in a case control study of community-dwelling premenopausal women with major depression”. J Clin Psychiatry. 2010 August; 71(8): 1079–87. 16.Angelina R. Sutin, Antonio Terracciano,1 Barbara Deiana, Manuela Uda, David Schlessinger, Edward G. Lakatta, and Paul T. Costa, Jr. “Cholesterol, Triglycerides, and the Five-Factor Model of Personality”. Biol Psychol. 2010 May; 84(2): 186–91. 17.Wieselmann G, Fabisch H, Herzog G, Fabisch K, Probst C, Langs G, Zapotoczky HG. “Effect of mianserin and additional fluid intake on depression and blood urea concentration in elderly patients”. [Article in German]. Wien Klin Wochenschr. 1994;106(3):89-91. 18.Giovanni Cizza, Sima Mistry, Vi T. Nguyen, Farideh Eskandari, Pedro Martinez, Sara Torvik, James C. Reynolds, Philip W. Gold, Ninet Sinai, Gyorgy Csako. “Do Premenopausal Women with Major Depression Have Low Bone Mineral Density? A 36-Month Prospective Study”. PLoS One. 2012; 7(7): e40894. 19.De Berardis D, Conti CM, Campanella D, Carano A, Di Giuseppe B, Valchera A, Tancredi L, Serroni N, Pizzorno AM, Fulcheri M, Gambi F, Sepede G, Moschetta FS, Salerno RM, Ferro FM. “Evaluation of plasma antioxidant levels during different phases of illness in adult patients with bipolar disorder”. J Biol Regul Homeost Agents. 2008 Jul-Sep;22(3):195-200. 20.Premachandra BN, Kabir MA, Williams IK. “Low T3 syndrome in psychiatric depression”. Journal of Endocrinological Investigation. 2006;29(6):568–72. 21.Donna Kritz-Silverstein, Stephen T. Schultz, Lawrence A. Palinkas, Deborah L. Wingard, and Elizabeth Barrett-Connor. “The Association of Thyroid Stimulating Hormone Levels with Cognitive Function and Depressed Mood”. J Nutr Health Aging. 2009 April; 13(4): 317–21. 22.Fraser SA, Kroenke K, Callahan CM, Hui SL, Williams JW Jr, Unützer J. “Low yield of thyroid-stimulating hormone testing in elderly patients with depression. Gen Hosp Psychiatry. 2004 Jul-Aug;26(4):302-9. 23.Kim JM, Stewart R, Kim SY, Bae KY, Yang SJ, Kim SW, Shin IS, Yoon JS. “ Thyroid stimulating hormone, cognitive impairment and depression in an older korean population”. Psychiatry Investig. 2010 Dec;7(4):264-9. 24.Barrett-Connor et al. “Bioavailable Testosterone and Depressed Mood in Older Men: The Rancho Bernardo Study”. J Clin Endocrinol Metab 1999; 84:573-7. 25.Ai-Min Baoa, Yi-Fu Jic, Eus J.W Van Somerend, Michel A Hofmand, Rong-Yu Liub, Jiang-Ning Zhou. “Diurnal rhythms of free estradiol and cortisol during the normal menstrual cycle in women with major depression” Hormones and Behavior; 2004;45( 2): 93–102. 26.Jadwiga Piwowarska, Magorzata Wrzosek, Maria Radziwoñ-Zaleska, Beata Ryszewska-Pokraoeniewicz, Micha Skalski, Halina Matsumoto, Agata Biernacka-Bazyluk, Waldemar Szelenberger, Jan Pachecka. “Serum cortisol concentration in patients with major depression after treatment with clomipramine”. Pharmacol Rep. 2009 Jul-Aug;61(4):604-11. 27.Bhagwagar Z, Hafizi S, Cowen PJ. “Increased salivary cortisol after waking in depression”. Psychopharmacology, 2005;182:54–7. 28.Stokes PE. “The potential role of excessive cortisol induced by HPA hyperfunction in the pathogenesis of depression”. Eur Neuropsychopharmacol, 1995;5, Suppl: 77–82. 29.Emma K. Adam, Leah D. Doane, Richard E. Zinbarg, Susan Mineka, Michelle G. Craske, and James W. Griffith. “Prospective prediction of major depressive disorder from cortisol awakening responses in adolescence.Psychoneuroendocrinology. 2010 July; 35(6): 921–31. 30.D. Mangold, E. Marino, and M. Javors. “The Cortisol Awakening Response Predicts Subclinical Depressive Symptomatology in Mexican American Adults”. J Psychiatr Res. 2011 July; 45(7): 902–9. 31.Wurtman RJ, Wurtman JJ. “Brain serotonin, carbohydrate-craving, obesity and depression”. Obes Res. 1995 Nov; 3 Suppl 4:477S-80S. 32.Elisabeth Maurer-Spurej, Cheryl Pittendreigh, and Shaila Misri. “Platelet serotonin levels support depression scores for women with postpartum depression”. J Psychiatry Neurosci. 2007 January; 32(1): 23–9. 33.Lawson R. Wulsin, MD, Dominique Musselman, MD, Christian Otte, MD, Erica Bruce, MPH, Sadia Ali, MPH, and Mary A. Whooley, MD. “Depression and Whole Blood Serotonin in Patients With Coronary Heart Disease From the Heart and Soul Study”. Psychosom Med. 2009 April; 71(3): 260–5. 34.Ulrich Schweiger, Md, Michael Deuschle, Md, Bettina Weber, Md, Andreas K¨Orner, Md, Claas-Hinrich Lammers, Md, J ¨Urgen Schmider, Md, Ulrike Gotthardt, Md, And Isabella Heuser, Md. Testosterone, Gonadotropin, And Cortisol Secretion In Male Patients With Major Depression. Psychosomatic Medicine .1999; 61:292–6. 35.Rubin RT, Poland RE, Lesser IM. Neuroendocrine aspects of primary endogenous depression VIII. Pituitary-gonadal axis activity in male patients and matched control subjects. Psychoneuroendocrinology. 1989; 14(3):217-29. 36.Cooper AJ, Finlayson R, Velamoor VR, Magnus RV, Cernovsky Z. Effects of ECT on prolactin, LH, FSH and testosterone in males with major depressive illness. Can J Psychiatry. 1989 Nov;34(8):814-7. 37.Matsunaga H, Sarai M. Elevated serum LH and androgens in affective disorder related to the menstrual cycle: with reference to polycystic ovary syndrome. Jpn J Psychiatry Neurol. 1993 Dec;47(4):825-42. 38.Teijamari Laasonen-Balk, Jyrki Kuikka, Heimo Viinamäki, Minna Husso-Saastamoinen, Johannes Lehtonen, Jari Tiihonen. Striatal dopamine transporter density in major depression. Psychopharmacology. 1999;144(3):282-5. 39.David J. Brunswick, Ph.D.; Jay D. Amsterdam, M.D.; P. David Mozley, M.D.; Andrew Newberg, M.D. Greater Availability of Brain Dopamine Transporters in Major Depression Shown by [99mTc]TRODAT-1 SPECT Imaging. Am J Psychiatry 2003;160:1836-41. 40.Janowsky DS, El-Yousef MK, Davis JM, et al. Parasympathetic suppression of mania by physostigmine. Arch Gen Psych. 1973; 28(4):542-7. 41.David S. Janowsky, Khaled El-Yousef, John M. Davis. Acetylcholine and Depression. Psychosomatic Medicine May 1, 1974 vol. 36 no. 3 248-57. 42.El-Yousef MK, Janowsky DS, Davis JM, et al. Induction of severe depression by physostigmine in marijuana intoxicated individuals, Br J Addict. 43.Philip NS, Carpenter LL, Tyrka AR, Price LH. The nicotinic acetylcholine receptor as a target for antidepressant drug development. Scientific World Journal. 2012; 2012:104-5. 44.Darko DF, Risch SC, Gillin JC, Golshan S. Association of beta-endorphin with specific clinical symptoms of depression. Am J Psychiatry. 1992 Sep;149(9):1162-7. 45.Hurd YL. Subjects with major depression or bipolar disorder show reduction of prodynorphin mRNA expression in discrete nuclei of the amygdaloid complex. Mol Psychiatry. 2002;7(1):75–81. 46.Chartoff EH, Papadopoulou M, MacDonald ML, et al. Desipramine reduces stress-activated dynorphin expression and CREB phosphorylation in NAc tissue. Mol Pharmacol. 2009;75(3):704–12. 47.Shirayama Y, Ishida H, Iwata M, et al. Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects. J Neurochem. 2004;90(5):1258–68. 48.Denis F. Darko, Michael R. Irwin, S. Craig Risch J. Christian Gillin. Plasma beta-endorphin and natural killer cell activity in major depression: A preliminary study. Psychiatry Research. 1992; 43(2) :111–9. 49. Alexopoulos GS, Inturrisi CE, Lipman R, Frances R, Haycox J, Dougherty JH, Rossier J. Plasma Immunoreactive β-Endorphin Levels in Depression. Effect of Electroconvulsive Therapy. Arch Gen Psychiatry. 1983;40(2):181-3. 50.Heninger GR, Charney DS, Sternberg DE. Serotonergic function in depression. Prolactin response to intravenous tryptophan in depressed patients and healthy subjects. Arch Gen Psychiatry. 1984 Apr;41(4):398-402. 51.Sher L, Oquendo MA, Li S, Ellis S, Brodsky BS, Malone KM, Cooper TB, Mann JJ. Prolactin response to fenfluramine administration in patients with unipolar and bipolar depression and healthy controls. Psychoneuroendocrinology. 2003 May;28(4):559-73. 52.Fava M, Vuolo RD, Wright EC, Nierenberg AA, Alpert JE, Fenfluramine challenge in unipolar depression with and without anger attacks. Rosenbaum JF.Psychiatry Res. 2000 Apr 24;94(1):9-18. 53.Maurizio Fava, M.D., Irving Hwang, M.A., A. John Rush, M.D., Nancy Sampson, B.A., Ellen E. Walters, M.S., and Ronald C. Kessler, Ph.D. The Importance of Irritability as a Symptom of Major Depressive Disorder: Results from the National Comorbidity Survey Replication. Mol Psychiatry. 2010 August; 15(8): 856–67. 54.de Almeida Pdel V, Gregio AM, Machado MA, de Lima AA, Azevedo LR. Saliva Composition and Functions: A Comprehensive Review. J Contemp Dent Pract. 2008; 9:72-80. 55.Grigoriev IV, Nikolaeva LV, Artamonov ID. Protein content of human saliva in various psychoemotional states. Biochemistry (Mosc). 2003; 68:405-6. 56.Johannsen A, Rylander G, Söder B, Asberg M. Dental plaque, gingival inflammation, and elevated levels of interleukin-6 and cortisol in gingival crevicular fluid from women with stress-related depression and exhaustion. J Periodontol. 2006 Aug;77(8):1403-9. 57.Kiran Chaudhari, S. Khanzode, S. Khanzode, G. Dakhale, A. Saoji, S. Sarode. Clinical correlation of alteration of endogenous antioxidant-uric acid level in major depressive disorder. Indian J Clin Biochem. 2010 January; 25(1): 77–81. 58.Owen M. Wolkowitz, Victor I. Reus, Synthia H. Mellon. of sound mind and body: depression, disease, and accelerated aging. Clin Neurosci. 2011 March; 13(1): 25–39.
Competent interest:- The authors declare that they have no competing interests. Source of funding: - None
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