Property | Value |
Name | Effect of high altitude on immune system |
Description | Research article:-Physiology Ashish Goel1*, Desh Deepak2, Kranthi Kumar G3, Sanjay Kumar Jha4 & Tripura Lakshmi J5. 1Assistant Professor, 3Demonstrator, Department of Physiology, SRMS Institute of Medical Sciences, Bareilly, UP, India. 2Professor, Department of Physiology, VCSG Government Medical Sciences and Research Institute, Srinagar, Uttarakhand, India. 4Assistant Professor, Department of Community Medicine, Government Medical College, Haldwani, Nainital, Uttarakhand,India. 5Demonstrator, Department of Physiology, Karpagam Faculty of Medical Sciences & Research, Coimbatore, Tamil Nadu, India.
Abstract: Objective: The chronic exposure at high altitude represents an ideal model for evaluating the effects of hypobaric hypoxia. This study was designed to evaluate the effects of chronic hypoxia on immune response. Material and methods: In this study 300 healthy adults (150 of plains and 150 of high altitude) were taken. The white blood cell parameters were evaluated by blood samples using MS-9 automated hematology cell counter. Observations and results: The total white blood cell count of high altitude individuals were significantly higher as compared to people residing in plains. The monocyte count was significantly higher as compared to people residing in plains. There was a statistically significant difference in total leukocyte count between males of plains and high altitude, while the difference was not statistically significant between females of plains and high altitude respectively which indicated that haemopoietic response to altitude is markedly less in women than that usually observed in men. Conclusion: It can be concluded that the chronic altitude exposure might activate the immune response, which is indicated by high WBC count in the permanent residents of high altitude.
Key words:- High altitude, Chronic hypoxia, White blood cell count, Immune response.
References:- 1.Beall CM.Andean,Tibetan and Ethiopian patterns of adaptation to high altitude hypoxia Integr Comp Biol 2006; 46 (1):18-24. 2.Beall CM, Brittenham GM, Strohl KP, Blangero J, Blangero SW, Goldstein MC et al. Hemoglobin concentration of high-altitude Tibetans and Bolivian Aymara. American journal of Physical Anthropology 1998;106:385-400. 3.Stammers AD. The polymorphonuclear-lymphocyte ratio at an altitude of 5750 feet. J Physiol 1933;78:335-8. 4.Kaya H, Kyky Y, Akarsu E, Gundoddu M, Tekyn SB, Ynandi T. Hematological values of healthy adult population living at moderate altitude (1869m, Erzurum, Turkey). Turk J Haematol 2000;17(3):123-8. 5.Beidleman BA, Muza SR, Fulco CS, Cymerman A, Staab JE, Sawka MN et al. White blood cell and hormonal responses to 4300m altitude before and after intermittent altitude exposure. Clinical Science 2006;111:163-9. 6.Siques P, Brito J, Leon-Velarde F, Barrios L, Cruz JJDL, Lopez V et al. Hematological and lipid changes in sea-level natives after exposure to 3550m altitude for 8 months. High Altitude Medicine & Biology 2007;8(4):286-95. 7.Ermolao A, Travain G, Facco M, Zilli C, Agostini C, Zaccaria M. Relationship between stress hormones and immune response during high-altitude exposure in women. J Endocrinol Invest. 2009; 32(11):889-94. 8.Bain BJ. Ethnic and sex differences in the total and differential white cell count and platelet count.J Clin Pathol 1996;49:664-6. 9.Bain BJ. Normal ranges. In: Bain BJ.Blood cells: A practice guide. 4 th edition.Blackwellpublication,2007:212. 10.Rock PB, Marder TH. Additional problems in mountain environment. In: Rock PB. Medical Aspects of Harsh Environment (2),1997:832. 11.Facco M et al. Modulation of immune response by the acute and chronic exposure to high altitude. Med Sci Sports Exerc 2005; 37(5):768-74. 12.Meehan R, Duncan U, Neale L, Taylor G, Muchmore H, Scott N et al. Operation Everest II :Alterations in the immune system at high altitudes. Journal of Clinical Immunology 1988; 8(5): 397-406. 13.Hannon JP, Shields L, Harris CW. Effects of altitude acclimatization on blood composition of women. J Appl Physiol 1969;26(5):540-47.
Copyright © 2013 Goel Ashish et al., This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
|
Filename | Goel Ashish et al.(425-429).pdf |
Filesize | 213.83 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 01/06/2013 00:00 |
Viewers | Everybody |
Maintained by | Editor |
Hits | 4204 Hits |
Last updated on | 02/14/2013 09:38 |
Homepage | |
CRC Checksum | |
MD5 Checksum |