Property | Value |
Name | Attenuation of cardiovascular response during laryngoscopy and endotracheal intubation by using fentanyl with lignocaine. |
Description | Original article:- Anaesthesia Ranganathan.S1*, Saravanan D1, Hari Kumar S1 & Sumathi.K2. 1Department of Anaesthesia. 2Department of Biochemistry, Sree Balaji Medical College and Hospital, Chennai (Bharath University),India.
Abstract:- Background: A prospective comparative study was done on lignocaine versus lignocaine with fentanyl to observe the effect on cardiovascular response to laryngoscopy and endotracheal intubation. Materials & Methods: One hundred such elective surgical patients of active age group (16 -60 years) having American Society of Anesthesiologist (ASA) physical status I & II irrespective of surgical procedure were randomly assigned to one of the two groups of 50 each. Group I received injection lignocaine 1.5 mg/kg intravenously 2 minutes before induction of general anesthesia. Patients in group II received injection fentanyl2 mcg/kg body weight and injection lignocaine 1 mg/kg body weight intravenously 2 minutes before induction of general anesthesia. Hemodynamic parameter i.e. blood pressures (systolic blood pressure, diastolic blood pressure and mean blood pressure), heart rate, were monitored after intubation,5min,10 minutes following intubation. Results: There were statistically significant (p<0.001) increase in blood pressures, heart rate and rate pressure product in group I i.e. pretreatment with 1.5 mg/kg body weight intravenous lignocaine and remained so after 10 minutes. On the other hand there were no statistically significant (p>0.05) increase in heart rate, blood pressures and in group II, where pretreatment done with fentanyl 2 mcg/kg body weight with lignocaine 1 mg/kg body weight and the values returned control level before 5 minutes. Conclusion: The study showed that fentanyl 2 mcg/kg body weight with lignocaine 1 mg/kg body weight pretreatment suppresses the cardiovascular response due to laryngoscopy and intubation.
Keywords:- Endotracheal intubation, laryngoscopy, lignocaine ,fentanyl.
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Copyright © 2013 Ranganathan S et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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