Property | Value |
Name | Assessment of nutritional status in hypothyroid patients |
Description | Research article:-Biochemistry Purnima Dey Sarkar1, Lincy K. Skaria2* & Gopinath Agnihotram 2 1Professor& HOD, 2 Research Scholar, Department. of Biochemistry, MGM Medical College, Indore, M.P, India.
Abstract:- Background: Thyroid disease results from a disruption of the endocrine and immune systems. Nutrition deficiencies cause a disruption of both the systems. The commonest thyroid disease is hypothyroidism with associated symptoms like fatigue, bradycardia, muscle hypotonia, female infertility, dry skin, etc. Methods: Total of 300 subjects were included in the study group of which 100 patients were hypothyroid, 50 patients were hypothyroid associated with women infertility along with 150 controls. Quantitative determination of thyrotropin (TSH), triiodothyroinine (T3) and tetraiodothyronine (T4) was analyzed along with nutritional analysis of dietary nutrients like carbohydrate, proteins, fat, vitamin A, B1, B2, C, niacin, etc. Biostatistical analysis and correlations were analyzed by using Graph pad prism software. Results:- The TSH levels in Hypothyroidism was 23.05 ± 13.05 and in hypothyroidism associated with infertility was 26.15 ± 13.36 and the difference between the two were significant (p<0.0001). The correlation between TSH and T4 in hypothyroidism was( r= -0.8447) and the correlation between TSH and T4 in hypothyroidism with infertility (r= -0.9137) are significant and is a negative correlation. Conclusion: The study concluded that the subjects in both the groups were deficient in almost all the dietary nutrients. Dietary zinc was found to be very low as suggested by ICMR, so there might be an interesting relationship between hypothyroidism and hypozincemia. Hence along with B-complex vitamins zinc also must be administered. Moreover fruits and vegetables must be included to meet the requirements of antioxidants such as β-carotene, Vitamin C and certain non-nutrients such as polyphenols and flavanoids.
Key words:- Hypothyroidism, Thyroid Stimulating Hormone(TSH), Triiodothyroinine (T3), Tetraiodothyronine(T4), Dietary Nutrients, Zinc.
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Filename | Lincy K. Skaria(582-585).pdf |
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Created On: | 02/05/2013 00:00 |
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Last updated on | 03/06/2013 10:00 |
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