Property | Value |
Name | Correlation of Syndecan-1 expression in oral squamous cell carcinoma and verrucous carcinoma |
Description | Research article:- Oral Pathology Ashok V1*, Prashant Babaji2, Nagarathna S3, Dilip Dhamankar4, Kiran Keswani5 & Raghavendra M Shetty6. 1Professor & HOD, Department of Oral Pathology, Bangalore Institute of Dental Sciences, Bangalore, India. 2Associate Professor, Department of Pedodontics,5Senior Lecturer Department of Conservative Dentistry and Endodontics, Vyas Dental College, Jodhpur, India. 3Professor , Department of Periodontics, Maharana Pratap Dental College, Gwalior, India. 4Professor & HOD, Department of Prasthodontics, NIMS Dental College, Jaipur, India. 6Professor, Department of Pedodontics, Chattisgarh Dental College, Rajanandagaon, India.
Abstract:- Syndecans are a family of integral membrane proteoglycans that participate in cell-matrix interactions and growth factor binding. The down regulation of syndecan-1 may offer the cell a possibility to detach and to invade. As the differentiation of cancer decreases, the expression of syndecan-1 also decreases. In our study we evaluated 63 cases of oral cancer for Syndecan-1 expression which comprised of 36 cases of oral squamous cell carcinoma and 27 cases of verrucous carcinoma. It was seen that the syndecan-1 expression showed a definite down regulation in squamous cell carcinoma and verrucous carcinoma. The staining intensity and percentage of positive cases decreased with increase in severity of squamous cell carcinoma.
Key words:- Squamous cell carcinoma, Syndecan-1, Verrucous carcinoma.
References:- 1.Bartold P M, Narayanan A S. Proteoglycans. Biology of the Periodontal Connective Tissues, Quintessence Publication.1998 2.Bernfield M et al. Biology of the syndecans. Annu. Rev Biochem.1992; 8: 365-93. 3.Soukka T et al. Reduction of syndecan-1 expression is associated with dysplastic oral epithelium. J Oral Pathol Med. 2000; 29: 308-13. 4.Jalkanen M, Rapraeger A, Saunders S et al. Cell surface Proteoglycan of Mouse Mammary Epithelial Cells is shed by Cleavage of its Matrix – binding Ectodomain from its Membrane Associated Domain.J. Cel Biol. 1987; 105: 3087-96. 5.Inki P et al. Immunohistochemical localization of syndecan-1. In normal and Pathological Human uterine Cervix. J. Pathol.1994; 172: 349-55.
Copyright © 2013 Ashok V et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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