Property | Value |
Name | Study of Pattern of drug resistance pulmonary tuberculosis patients attending tertiary care centre Allahabad who are sputum positive at microscopy centre under RNTCP |
Description | Original research article:-Pulmonary Medicine Gupta Ashish K1 ,Mehmood Tariq2 & Khan Mohd H3*. 1 Senior resident, Department of Pulmonary Medicine, Rural institute of medical sciences & research Safai, Etawa U.P, India. 2 Assistant Professor, Department of Pulmonary Medicine, Motilal Nehru Medical College (MLNMC), Allahabad, U.P, India. 3 Assistant Professor, Department of Community Medicine, Rohilkhand Medical College, Bareilly,(U.P), India.
Abstract:- Background: Both inadequate prescription and non-compliance with antituberculosis drugs have resulted in the emergence of a dreadful known as multi drug resistant (MDR) tuberculosis. Objective: 1.To find out prevalence of antituberculosis drug resistance pattern in suspected case of drug resistant Tuberculosis. 2. To find out predominant patterns of drug resistance and will useful in provides guidance on appropriate regimes for treatment of MDR tuberculosis. Study design: Hospital based study. Setting: Department of pulmonary medicine, Motilal Nehru Medical College (MLNMC), Allahabad, (U.P) India. Participants: 52 patients. Sampling: Purposive sampling method. Results: Out of 52 patients 23(44.23 %) were relapse, 22(42.30 %) were treatment failure and 7(13.46 %) were defaulter. Single drug Resistance was in 13 (25.49 %) patients. Single drug resistance to isoniazid in 7(13.7%) patient, Ethambutol 5(9.8%) patient and in streptomycin 1(1.96) patient. 10 (19.6%) patients were two drug resistance. The most common two drug combination pattern was isoniazid and ethambutol in 4(7.84%) patients followed by isoniazid and Pyrazinamide in 2(3.92) patients and in 1(1.96%) patients each of HR, RS, ZS and ES. 11 patients were 3 drug resistance. Most common three drug pattern was HZE and HRS 3(5.9%) each. five (9.8%) patients were 4 and >4 drugs resistance. Most common combination was HRZE in 2 (3.92%). Conclusion: There is an urgent need for timely identification of suspect of drug resistance by early referral for culture and drug sensitivity test for prompt initiation of appropriate treatment to improve outcome as well as to sever the chain of transmission.
Keywords:- Single drug resistance, Multi drug resistance, Defaulter, Treatment failure, Relapse. References:- 1.Surendra K. Sharma, Alladi Mohan. Tuberculosis 1st Edition 2001. Jaypee Brother Medical Publisher (P) Ltd. New Delhi, India 2.Pabloz-Mendez A, Raviglione MC, Laszle A. Binkin N, Rieder HL, Bustreo F. et al. Global surveillance for anti tuberculosis- drug resistance 1994-1997. N Eng J Med. 1998; 338: 1641-9. 3.Espinal M. Multi drug resistant tuberculosis: basis for the development of an evidence based case management strategy for Multi drug resistant tuberculosis within the WHO DOTS strategy. Proceedings of 1998 meeting and protocol recommendations, Geneva WHO 1999. 4.Espinal M. Raviglione M, Kochi A. Rational DOTS plus for the control of Multi drug resistance International J tuberculosis and lung disease 1999; 3: 561-3. 5.Desiree TB D'souza, Nerges F Mistry et al. High level of multi drug resistant tuberculosis in new and treatment failure patients from the revised national tuberculosis control programme in an urban metropolis (Mumbai) in Western India. BMC Public health 2007;10: 1186/1471 2458-9-211. 6.Lt. Col. RB Deoskar et al. Study of drug resistant pulmonary tuberculosis. MJAFI 2005; 61: 245-8. 7.Dam. T, M. Isa, and M. Bose et al. Drug sensitivity profile of clinical mycobacterium tuberculosis isolates-a retrospective study from a chest disease institute India. Journal of Medical microbiology 2005; 54: 269-71. 8.Saha AR, Agarwal SK, Saha KV. Study of drug resistance in previously treated tuberculosis patient in Gujarat, India (2000-2001). International J. of Tuberculosis and Lung disease 2002; 6 (12):1098-1101. 9.Hanif M, Malik S, Dhingra VK (2006). Acquired drug resistance pattern in tuberculosis cases at the state tuberculosis centre, Delhi, India. Int. J. tuber and lung diseases 2009;13(1): 74-8. 10.Anuradha B et al. Prevalence of drug resistance under the DOTS strategy in Hyderabad. South India, 2001-2003. International Journal of tuberculosis and lung disease 2006 Jan, 10(1): 58-62. 11.Javed A. Malik et al. Study of anti mycobacterium drug resistance in pulmonary tuberculosis in Kashmir, India Jr. for the Practicing Doctor 5 ( 4) :2008-09. 12.Janmeja AK. Raj B. Acquired drug resistance in tuberculosis in Haryana. J assoc. Physician India 1998 Feb, 46(2): 194-8. 13.B. Malhotra et al. Drug susceptibility profile of mycobacterium tuberculosis isolates at Jaipur. India Jr. of Medical microbiology. 2002;20 (2): 76-8.
Copyright © 2013 Gupta Ashish K,Mahmood Tariq & Khan Mohd H. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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