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Name | To Study the effect of haemoglobin levels on the induction dose of thiopentone. |
Description | Case report:- Anesthesia Pravin Sonuji Sapkal1*, Sudhir Chavan2, V A Kurhekar3, Sampda Rajurkar4 & Prerna Nandedkar5. 1Assistant Professor, 2Head of Department, Dept of Anesthesia, 4Assistant Professor Department of PSM, 5Assistant Professor Department of Biochemistry, Government medical college Akola, Maharashtra, India. 3Associate Professor, Dept of Anesthesia, Government medical college, Miraj, Maharashtra, India.
Abstract:- To Study the effect of Hemoglobin Levels on the induction dose of thiopentone. Background: Thiopentone is the most commonly used induction agent. Its fate is intimately related linked to magnitude of its binding protein, which is deranged in anemia, hypoprotienaemia and A: G ratio. Aim: To evaluate the effect of hemoglobin level alone on the induction dose of thiopentone with normal level of protein, albumin and globulin. Setting and Design: Clinical trial to evaluate the possible interaction between hemoglobin levels and induction dose of thiopentone with the normal levels of proteins like albumin and globulin. Methods and Materials: It is the clinical trial conducted on patients of both sexes between the age of 15-50yrs of ASA grade I and II who follows the criteria during the period of Jan 2010 to Sept 2011. Total 80 subjects are selected in the study. Statistical Analysis used: Z test is used to find the significance. SPSS 17 is used for analysis. Result and conclusion: Dose of thiopentone (MID) in cases is less than that of control group. And it is statistically highly significant. MID of thiopentone is larger in higher hemoglobin concentration. Present study suggests that normal patients vary enormously in their response to thiobarbiturates. The dose of thiopentone sodium required for induction of anesthesia is less in patients with low hemoglobin levels. This may be due to anaemic hypoxia increasing the sensitivity of cerebral cell to drugs. Keywords:- Hemoglobin, induction dose, thiopentone.
References:- 1.Evans AT. Manual of Obstratics.7th ed. Philadelphia: Lippincott William and Wilkins; 2007. p. 62. 2.Atkinsons AJ, Abernethy DR, Daniels CE, Dedrick RL.Principal of clinical pharmacology. 2nd ed. London: Elsevier; 2012. p. 84-9. 3.Dundee JW. Thiopentone narcosis in the presence of hepatic dysfunction. Brit. J. Anaestha 1952;24:81-100. 4.Dundee JW, Hassard TH et.al. The induction dose of thiopentone. A method of study and preliminary illustrative results. Anaesthesia, 1982; 37:1176-8. 5.Dundee JW, Hassard TH et.al. The influence of hemoglobin and plasma urea levels on the induction dose of thiopentone. Anaestesia, 1983;38:26-8. 6.Edwards R, Ellis FR et.al. clinical significance of thiopentone and plasma protiens. Brit. J. Anaesth. 1973; 45-891. 7.Malil L, Afzal L, Abraham V. A study to determine the correlation of hemoglobin levels on the induction dose of thiopentone. Ind. J. Anaesth, 1998;42:36-44. 8.Peterson RC, Shideman FE et.al. Prolongation of thiopental anesthasia by anoxia. Fed.Proc,1950;9:307-8. 9.Brodie BB,Marc LC et.al. The fate of thiopental in man and a method for the estimation in biological fluids. J.Phama Exp ther, 1950; 98: 85-7.
Copyright © 2013 Pravin S et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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