Property | Value |
Name | A model of temporal lobe epilepsy induced by kainic acid and the behavioral study of the animals treated with Acorus calamus and β-asarone |
Description | Research article:-Anatomy * C.Venkatramaniah¹, A.Mary Antony Praba² and Dr. Girija Sivakumar3. ¹Assistant Professor, Department of Anatomy, Sri Lakshmi Narayana Institute of Medical Sciences, Pondy, India. ²Assistant Professor, Department of Anatomy, Tagore Medical College, Chennai, India. 3Professor, Department of Anatomy, Karpagavinayaka Institute of Medical Sciences, Chennai, India.
Abstract:- Epilepsy is a common chronic neurological disorder characterized by seizures and affecting up to 1% - 2% of the population. Temporal lobe epilepsy is a major form of focal epilepsy. Herewith we produced a model of temporal lobe epilepsy by stereotaxically induced microliters of kainic acid into the right hippocampus. Animals were divided into 8 groups, vehicle control, lesion control, AC 15, AC 25, AC 35, BA 10, BA 15 and BA 20. Except the vehicle control and the lesion control group all the other groups of animals were given Calamus oil and Beta Asarone in different concentrations based on their group names. The behaviors of the animals were assessed by using Cook’s pole climbing apparatus. The vehicle control group of animals behaved normally. The lesion control animals exhibit epileptic seizure and was not performing in the pole climbing apparatus. The AC 15, BA 10 and BA 15 group of animals performed poorly as they did not climb the pole for all the ten times and they were more fearing than climbing the pole. The animal belongs to AC 25, AC 35 and BA 20 were climbed the pole immediately after hearing the buzzer sound and finished all the ten buzzers successfully. These data supports the neuroprotection of Acorus calamus and it’s principle component Beta Asarone.
Key Words:- AC= Calamus oil, BA = Beta Asarone, CAR= Conditioned avoidance response, VC= Vehicle control, LC= Lesion control, LD 50= Lethal dose 50, IP=Intraperitoneal.
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Filename | Venkatramaniah C , P Antony Mary A and Sivakumar G.pdf |
Filesize | 189.62 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 10/09/2012 00:00 |
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Maintained by | Editor |
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Last updated on | 04/03/2013 03:09 |
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