Property | Value |
Name | Effect of male sex hormone, Testosterone in Schizophrenic patients placed on Anti-psychotic medication, Chlorpromazine. |
Description | Research article:-Pharmacology 1Associate professor, Department of Pharmacology, 2Associate professor, Department of Anatomy, Jhalawar medical college, Jhalawar, Rajasthan, India.
Abstract:- Background:- There is great controversy about role of male sex hormone, testosterone, in Psychotic mental disorders like schizophrenia. This study assessed the effectiveness of testosterone in schizophrenic patients and probes how it modulates the action of standard anti-psychotic medication Chlorpromazine which is commonly used in Clinical Psychiatric practice. Methods, a. Design and Setting:- -Randomized, Double-blind, Controlled Clinical study performed in collaboration with Department of Clinical Psychiatry from Feb 2003 to March 2004 in M.Y.H Hospital (Teaching hospital) associated with M.G.M. Medical College, Indore. b. Subjects - twelve patients aged 20 to 60 years diagnosed Schizophrenics according to ICD-10 Criteria who visited in outpatient department of psychiatry during study period. c. Interventions - Patients was treated with Oral Chlorpromazine 200 mg BD, half of the 12 patients also received single dose of testosterone esters 100mg intramuscularly with above-mentioned treatment .d. Outcome Measure - how symptomology in schizophrenic patients affected is measured by applying various valid psychiatric rating scales like Brief psychiatric Rating Score (BPRS) , Scale for assessment of positive symptom(SAPS), and Scale for Assessment of Negative Symptoms (SANS) . Basal reading is followed by treatment intervention and then scales are used to measure the effect every week for 3 weeks. Paired‘t’ test is used for determining level of significance (p value) of intervention. Results: - Single dose of Testosterone 100 mg administered initially by I.M. route potentiated the reduction level in negative symptoms of schizophrenia by 115% in patients receiving chlorpromazine 200 mg. Conclusion:- In this study, Testosterone potentiated the effects of Chlorpromazine 200 mg, on general psychotic manifestations, positive symptoms and negative symptoms of schizophrenia, assessed on BPRS, SAPS and SANS scoring scales. The most significant is the effect on negative symptoms as measured by SANS.
Keywords:- Testosterone, Schizophrenia, Chlorpromazine.
References:- 1.Kaplan HI, sadock’s BJ, comprehensive Glossary of psychiatry and psychology .Baltimore, MD: Williams and Wilkins; 1995. 2.Brady N, McCain GC. Living with schizophrenia: a family perspective. Online J Issues Nurs 2004; 10:7. 3.Crow TJ: the Two syndrome concept: origins and current status .schizophr Bull 1985; 11: 471. 4.Kahn RS and Davis KL: New developments in dopamine and schizophrenia. In Psychopharmacology: The fourth generation of progress (ed.) F.E. Bloom and DJ Kupter. Raven Press, New York 1995; 1193-204. 5.Coyle JT, Tsai G, Goff D. Converging evidence of NMDA receptor hypofunction in the Pathophysiology of schizophrenia. Ann J Y Acad Sci.2003; 1003:318. 6.Pope HG Jr, Katz DL: psychiatric and medical effects of anabolic –androgenic steroid use .Arch Gen Psychiatry. 1994; 51:375. 7.Kulkarni J, Riedel A, de Castella AR, Fitzgerald PB, Ralfe TJ, Taffe J, Burger: A clinical trial of adjunctive estrogen treatment in women with schizophrenia. Arch Women Ment Health Nov 2002;5(3):99-104. 8.Anthony decastella, Alan Booth DA Granger: The effect of schizophrenia on sex hormones blood levels. Psychiatric Services 2002; 53:600-03. 9.Eto K, Kimura H: The production of hydrogen sulfide is regulated by testosterone and S-Adenosyl-L-methionine in mouse brain. J Neurochem 2002 Oct; 83(1):80-6. 10.Goldstein JM, Link BG. Gender and the expression of schizophrenia. J Psychiatry Res 1988; 22:141-55 11.Lewine R. Schizophrenia: an Amotivational syndrome in men. Can J Psychiatry 1985; 30:316-8. 12. E B Strauss, D E Sands, A M Robinson, W J Tindall, dehydroisoandrosterone in psychiatric treatment ,W A H Stevenson British medical journal 08/1952; 2(4775):64-6.Source: PubMed. 13.58. O’Connor DB, Archer J, Hair WM, Wu FC. Exogenous testosterone, aggression, and mood in eugonadal and hypogonadal men. Physiol Behav 2002; 75:557–66.
Copyright © 2013 Vijaywargia Tarun & Sharma Gopal. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
|
Filename | Vijaywargia Tarun et al.(660-666).pdf |
Filesize | 240.36 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 03/05/2013 00:00 |
Viewers | Everybody |
Maintained by | Editor |
Hits | 2167 Hits |
Last updated on | 04/03/2013 08:53 |
Homepage | |
CRC Checksum | |
MD5 Checksum |