Property | Value |
Name | Role of serology in establishing association between pathogen burden and coronary artery disease |
Description | Original article:- M. D. Dixit1, Kishore Bhat2*, Mohan D. Gan3 & Aruneshwari Dayal3 1Head of the Department & Professor,2Research Officer,3Professor,CVTS,Jawaharlal Nehru Medical College and Karnataka Lingayat Educational Society’s Dr.Prabhakar Kore Hospital & Medical Research Centre, Belgaum, Karnataka, India.
Abstract:- Background and Objectives: Several chronic microbial infections are being considered as newer risk factors for atherosclerosis and CAD. But the reports are conflicting and the published data from India is scarce. An attempt has been made in the present study to evaluate the role of pathogen burden in subjects with and without CAD in a Tertiary Care Hospital in Karnataka,India. Methods: Seropositivity to IgG antibodies specific for Chlamydia pneumoniae, Helicobacter pylori, Herpes simplex virus type 1 and 2 and Cytomegalovirus was investigated in 274 patients with CAD and 275 apparently healthy individuals by ELISA test. The presence of conventional risk factors including hyperlipidemia, hypertension, diabetes, smoking and BMI were recorded. Occurrence of angina and MI also were noted. Results: There was a significant difference in the incidence of CMV, H. pylori and C. pneumoniae between CAD patients and controls, but the association was weak after multivariate analysis. On the other hand, pathogen burden was significantly higher in study group. The presence of risk factors was very high in patients (73.82%) in contrast to controls (11.3%). The association between MI and pathogen burden was statistically significant. Interpretation and conclusion: our data provide strong evidence that pathogen burden may have direct bearing on the incidence of CAD and also on the occurrence of cardiac complications such as MI. On the other hand, the association of individual infections with CAD appears to be weak. More such studies, prospective in nature are needed before definite conclusions can be drawn.
Keywords:- Coronary Artery Disease, H. pylori, C. pneumonia, HSV, CMV, Risk factors, Myocardial infarction & Pathogen burden.
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Copyright © 2013 Bhat Kishore et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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