Property | Value |
Name | Comparison of postoperative analgesic efficacy of intrathecal clonidine with hyperbaric bupivacaine in lower abdominal surgeries |
Description | Research article:- Anaesthesia, Meera Rani Nayak* Assistant Professor, Department of Anaesthesia, Sree Balaji Medical College & Hospital, #7, Works Road, Chromepet, Chennai - 600 044.Tamil Nadu, India.
Abstract:- This study was carried out in 60 adult ASA I &II patients to evaluate prolongation of postoperative spinal analgesia by clonidine. Addition of intrathecal clonidine at the doses of 75µg & 37.5µg to 0.5% hyperbaric Bupivacaine prolongs both sensory blockade of spinal anaesthesia & time interval to first request for supplemental analgesia. Incidence of hypotension & bradycardia was more with higher doses of intrathecal clonidine (75µg) which was managed by I.V fluids, inj. Mephenteramine & inj. Atropine sulphate satisfactorily. Sedation – maximum with higher dose (75µg) of intrathecal clonidine. Key words:- Intrathecal clonidine, Post operative analgesia, Lower abdominal surgeries.
References:- 1.Bonica J. Postoperative pain. In: Bonica J, ed. The management of pain. 2nd ed. Philadelphia: Lea & Febiger, 1990:461-80. 2.Eisenach J, De kock M, Klimscha W. alpha 2 adrenergic agonists for regional anaesthesia: aclinical review of clonidine (1994 - 1995). Anesthesiology 1996; 85:655-74. 3.Filos KS, Goudas LC, Patroni, Polyzou V. haemodynamic & analgesic profile after intrathecal clonidine in Humans. A dose response study. Anesthesiology 1994; 81: 591-601. 4.Niemi L. Effects of intrathecal clonidine on duration of Bupivacaine spinal anaesthesia , hemodynamics, postoperative analgesia in patients undergoing knee artroscopy. Acta Anaesth Scand 1994; 38:724-8. 5.Bonnet F, Brun –Bisson V, Saada M. Dose related prolongation of hyperbaric tetracaine spinal anaesthesia by clonidine in humans. Anaesthe Analg 1989; 68; 619-22. 6.Pettibone DJ,Mueller GP. Alpha adrenergic stimulation by clonidine increases plasma concentration of immunoreative β endorphins in rat . Endocrinology 1981;109:798-802. 7.Sites BD, Beach M, Biggs R , Rohan C, Wiley C, Rassias A, et al. Intrathecal clonidine added to a bupivacaine – morphine spinal anaesthetic improves postoperative analgesia for total knee artroplasty. Anesth Analg 2003;96:1083-8. 8.Vaghadia H, McLeod DH, Mitchell GW, Merrick PM, Chilvers CR. Small-dose hypobaric lidocaine –fentanyl spinal anaesthesia for short duration out patient laparoscopy. I. A randomized comparison with conventional dose hyperbaric lidocaine. Anesth Analg 1997; 84:59-64. 9.Eisenach JC, De Kock M, Klimscha W, Alpha(2) – adrenergic agonists for regional anesthesia. A clinical review of clonidine (1984-1995).Anesthesiology 1996;85:655-74. 10.Kaabachi O, Zarghouni A, Ouezini R, Abdelaziz AB, Chattaoui O, Kokki H.Clonidine 1 microg/kg is a safe and effective adjuvant to plain bupivacaine in spinal anesthesia in adolescents. Anesth Analg 2007; 105:516-9. 11.Eisenach J,Detweiter D,Hood D. Hemodynamic and analgesic action of epidurally administered clonidine. Anesthesiology 1993; 78:277-87. 12.Nader ND,Ignatowski TA,Kurek CJ,Knight PR, Spengler RN. Clonidine suppresses plasma and cerebrospinal fluid concentrations of TNF-alpha during the perioperative period. Anesth Analog 2001; 93:363-9. 13.Larsen B, Dorscheid E, Macher-Hanselmann F,Buch U.Does intrathecal clonidine prolong the effect of spinal anesthesia with hyperbaric mepivacaine? A randomized double-blind study. Anesthesist 1998; 47:741-6.
Copyright © 2013 Meera Rani Nayak. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
|
Filename | Meera Rani Nayak.(701-704).pdf |
Filesize | 238.72 kB |
Filetype | pdf (Mime Type: application/pdf) |
Creator | admin |
Created On: | 03/06/2013 00:00 |
Viewers | Everybody |
Maintained by | Editor |
Hits | 2839 Hits |
Last updated on | 04/05/2013 05:22 |
Homepage | |
CRC Checksum | |
MD5 Checksum |