Property | Value |
Name | Antimicrobial susceptibility pattern of pseudomonas aeruginosa. |
Description | Original article:- Microbiology Prashanth HV1, Prakash R2, Girishbabu RJ2,Atiya Kausar3 & Mrs. Veena Krishnamurthy4
1Professor, 2Assistant Professor, 3Post graduate(MD)cum Tutor , 4 Assistant Professor MSc (PhD) , Department of Microbiology, Sri Siddhartha Medical College, Tumkur. – 572107, Karnataka, India.
Abstract:- Background: Pseudomonas aeruginosa (P. aeruginosa) is a gram negative bacterium that continues to be a major cause of opportunistic nosocomial infections, causing around 9-10% of hospital infections. The rapid increase of drug resistance in clinical isolates of this opportunistic human pathogen is a worldwide concern. Unfortunately, P. aeruginosa demonstrates resistance to multiple antibiotics, thereby jeopardizing the selection of appropriate treatment. Aims & Objectives: This study was undertaken to find out the antibiotic resistance pattern of pathogenic isolates of P. aeruginosa from various specimens. Settings and Design: Hospital based Prospective study. Materials & Methods: 124 pseudomonas positive samples from various samples were included in this study. Antibiotic susceptibility pattern was tested as per CSLI guidelines. Statistical Analysis: The results were presented using proportions. Results: Highest percentage of P. aeruginosa was isolated in pus samples. The resistance was highest for ceftazidime (79%), followed by ceftriaxone (73%), cefepime (73%), cotrimoxazole (72.3%) and lowest for imipenem (5.1%). The rate of aminoglycoside resistance was found to be relatively high (amikacin- 46.7% & gentamicin 49.5%). Conclusions: P. aeruginosa is one of the most important bacterial pathogen seriously contributing to the problem of healthcare associated infection. Amikacin seems to be a promising therapy for pseudomonas infection. Hence its use should be restricted to serve nosocomial infections in order to avoid rapid emergence of resistance strains. Hence there is a need to emphasize the rational use of antimicrobial & strictly adhere to the concept of reserve drugs to minimize the misuse of available antimicrobials.
Keywords:- Pseudomonas aeruginosa, Antimicrobial susceptibility.
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Copyright © 2013 Prashanth et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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