Property | Value |
Name | Non HDL-C as an alternate to LDL-C for the diagnosis of Cardio Vascular Disease |
Description | Research article:- Biochemistry Priya.G 1, Revathy.K 2*, Emila.S 3, Swaminathan.S 2** 1Senior Technical Officer, Department of Biochemistry, Apollo Specialty Hospital, Chennai – 600035, India. 2*Ex. Junior Technical Officer & ** Ex. Senior Consultant & Head Department of Biochemistry, Apollo Speciality Hospital, Chennai – 600035, India. 3Lab Technologist, Department of Biochemistry, SRM Institute for Medical Sciences, Chennai -600026,India.
Abstract:- To investigate the association between Non-High Density Lipoprotein-Cholesterol (Non-HDL–C) to various other lipid profile tests and to recommend its clinical usefulness in the diagnosis of Cardio Vascular Disease (CVD). Materials and methods: This study was carried out using lipid profile tests Total Cholesterol, High Density Lipoprotein-C, Low Density Lipoprotein – C and Triglycerides (TC, HDL-C, LDL-C, Tg) for 500 patients (350 males, 19 – 79 years and 150 females, 23- 85 years) over a period of one month. Measurements of the above analytes were done using state of art automated analysers and internationally accepted reagent kits. Appropriate accuracy controls were employed to validate the accuracy of the results obtained. Non HDL-C was calculated as the difference between TC& HDL-C. The results obtained were subjected to statistical analysis to calculate r, t, & p values and the association between Non HDL-C and other lipid profile tests were calculated to find out r, t and p values. A p value of less < 0.05 indicates significant association with other lipid profile viz TC, LDL-C, and Tg. Results: A highly significant association (p<0.0001) for non HDL-C with TC, LDL-C, Tg were obtained indicating that this parameter may serve an alternate to LDL-C. Conclusion: This study is based on a large number of patients and the results obtained suggest the usefulness of non HDL-C as an index of assessing cardiac function. This approach is easy to arrive at and which represents all fractions of cholesterol except HDL-C. Further this approach will avoid measuring LDL-C, an expensive testing procedure. Non-HDL-C which contain all fractions other than HDL-C and which are responsible for plaque and atherosclerosis formation, may help in the diagnosis of CVD.
Keywords:- Lipid Profile, CVD, HDL-C, LDL-C, TC, Tg, CHD, VLDL, NHDL-C, apoB, Lp(a).
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Copyright © 2013 Swaminathan. S et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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