Property | Value |
Name | Antidiabetic and hypolipidaemic effects of Cicer arientinum seeds extracts in hyperglycemic and diabetic rats |
Description | Research article:- Mustafa A. Howeida 1, Eltayeb B. Idris 2, Ali M. Almahdi 3, Shaddad A. Sania4 & Mohammad H. Abdelwahhab5 1Department of Biochemistry and Pharmacology, School of Medicine, Ahfad University, Omdurman, Post box 167, Sudan. 2 Faculty of Pharmacy, Department of Pharmacology, University of Khartoum, Post box 321, Sudan. 3Faculty of Medicine. Department of Internal Medicine, University of Khartoum, Post box 321,Sudan. 4Faculty of Pharmacy. Department of Pharmacology, University of Khartoum, Post box 321, Sudan. 5Medicinal and Aromatic Plants`s Research Institute (MAPRI), National Centre for Researches,Mac Nimr Street, Khartoum, Sudan.
Abstract :- Objective: The aqueous and methanolic extracts of the seeds of C.arientinum were studied for their antidiabetic and hypolipidaemic effects in hyperglycaemic (type II) and in diabetic rats (type I). Method: Type II was induced using an intraperitonial (i/p) loading dose of glucose while type I was induced by injection of Streptozotocin (i/p). The plant extracts were given orally. The hypoglycaemic effect was determined following the Glucose tolerance test (GTT) model and the results were compared to the control. Results: The results showed that the onset of the hypoglycaemic effect of C. arientinum in type II was earlier and more persistent than in type I, as it started since the 1st hour post dosing and continued throughout the experiment. Dose 400 mg ∕ kg of the aqueous extract, exerted the highest significant glucose lowering effect (P <0.001) since the 1st hour in type II and at the 12th hour in type I. The onset of the hypocholesterolaemic effect of the methanolic extract of C.arientinum, was earlier, persistent and highly significant (P <0.001) in type II than in type I as it started since the 1st hour post dosing and continued throughout the experiment. The aqueous extract, showed a lower significance (P <0.05) and a shorter duration of action in type II. None of the extracts showed a hypocholesterolaemic effect in type I. The reference drugs Insulin and Glibenclamide showed significant reductions (P <0.05) at the 2nd hour in type II and the 4th hour in type I. The methanolic extract in both types of diabetes, showed an early significant triglycerides lowering effect (P <0.05) since the 1st hour. Doses 200 mg ∕ kg of the methanolic extract reduced triglycerides level significantly (P <0.001) at the 4th hour in type II and the 12th hour in type I, similar to both doses of the aqueous extract in type I. Insulin induced a significant reduction (P <0.05) throughout the experiment. Conclusion: the seeds of C. arientinum confirmed its traditional use in herbal medicine as an antidiabetic agent which can be more effective than the commonly used hypoglycaemic drugs.
Key Words:- Hyperglycaemia, Hyperlipidaemia, Albino Rats, Herbal Medicine, C.arientinum.
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