Property | Value |
Name | Hypoglycemic effect of aqueous and ethyl acetate extracts of Senna spectabilis in alloxan induced diabetic male mice |
Description | Research article:- Geoffrey Muriira Karau1, 2*, Eliud Nyagah Mwaniki Njagi1, Alex King’ori Machocho3, Laura Nyawira Wangai4, Peter Ng’aru Kamau5 & Paul Bundi Karau6
Affiliations:- 1Department of Biochemistry and Biotechnology, Kenyatta University, P.O Box 43844-00100, Nairobi, Kenya. 2Kenya Bureau of Standards, P.O Box 54974-00200, Nairobi, Kenya. 3Department of Chemistry, Kenyatta University, P.O. Box 43844-00100, Nairobi,Kenya. 4Department of Biochemistry and Molecular Biology, Jomo Kenyatta University of Agriculture and Technology, P.O Box 62000-00200, Nairobi, Kenya. 5Research and Development Division, Mount Kenya University, P. O Box 342-01000, Thika, Kenya. 6Kenya Methodist University, School of Medicine and Health Sciences, P. O Box 267-60200, Meru, Kenya.
Abstract:- Senna spectabilis D. C Irwin has been used as a forkloric medicine to manage diabetes mellitus by the communities in south eastern part of Kenya. The present study evaluated in-vivo hypoglycemic activity of the aqueous and ethyl acetate extracts of S. spectabilis. The study used six groups of mice each of five mice. Diabetes mellitus was induced in five groups with 10% alloxan monohydrate at a dose of 186.9 mg/kg body weight. Non-diabetic control mice was orally administered with 0.1 ml physiological saline; diabetic mice with 0.075 mg of reference drug, glibenclamide at 3 mg/kg body weight; 1.25 mg, 2.5 mg, and 5 mg leaf and stem barks aqueous and ethyl acetate extracts in 0.1 ml physiological saline for 50, 100 and 200 mg/kg body weight, and the other group of diabetic mice was given 0.1 ml physiological saline. Blood glucose level was determined after 0, 2, 4, 6 and 8 hours. S. spectabilis exhibits a significant hypoglycemic activity in both aqueous and ethyl acetate extracts. The activity is either dose dependent or independent for the leaves and stem barks extracts, respectively. The study findings validate the forkloric use of this plant among the local communities of south eastern Kenya.
Key Words: Senna spectabilis, hypoglycemic activity, diabetic BALB/c mice, ethyl acetate extract and aqueous extract.
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Copyright © 2013 Karau Muriira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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