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Name | Analysis of Liver Dysfunction among Sickle Cell Disease Population in Bastar Region of Chhattisgarh |
Description | Research article:- Purnima Dey Sarkar1, Gopinath Agnihotram2, Lincy K.Skaria3 1Professor & Head, Department of Biochemistry, M.G.M. Medical College, Indore, M.P, India. 2Demonstrator,3 Assistant professor, Department of Biochemistry, Govt. Medical College, Jagdalpur, Chhattisgarh, India.
Abstract: Objective:- The present study aims to investigate regular liver function tests with serum iron and its associated parameters in sickle cell disease patients to understand their clinical significance in relation to transfusion with evaluating the prevalence and morbidity patterns of liver dysfunction in the people of Tribal rich Bastar region. Methods: The present study was conducted at Govt.Medical College, Jagdalpur and comprised of 190(86.36%) patients with an established diagnosis of sickle cell disease, of which 60(27.27%) were diagnosed as sickle cell heterozygous (HbSC) and among them 18(8.18%) were having β-Thalassemia and remaining 130(59.10%) patients were with homozygous sickle cell (HbSS) disease, among them 70(31.81%) are classified in to 4 different groups based on their type of liver disorder like Viral Hepatitis(n=20,9.09%),Cirrhosis due to Iron overload (n=15,6.81%), Sickle cell Hepatopathy (n=20,9.09%), Cholelithiasis and Choledocholithiasis (n=15,6.81%), along with this patient population we have taken 30(13.63%) Age and Sex matched healthy persons as controls. Results: MCV and RDW-CV levels were significantly high (p<0.001), RBC and PCV are significantly low(p<0.001) in sickle cell disease. AST, ALT, ALP(p<0.001) and GGT (p<0.001)are elevated in all types of liver dysfunction. LDH (p<0.05) was positively correlated (r=0.3840) with increased levels of serum bilirubin (p<0.001) serum iron and ferritin (p<0.1), Transferrin and Total Iron Binding Capacity (p<0.1) are not statistically significant except in cirrhosis due to iron over load. Conclusion: By this we concluded that the prevalence of liver dysfunction in sickle cell disease population is high in Bastar population, compared to other regions of India and the indication criteria for chelation therapy was advised to reduced from serum ferrritin >3000ng/ml and hepatic iron content >7-9mg/gm.dry weight to >2000ng/ml and 5-7mg/gm.dry weight, respectively in our population.
Keywords:- sickle cell disease, sickle cell trait, Sickle Cell Hepatopathy, Liver Biopsy, TIBC, Hepatic Iron Content. |
Filename | Agnihotram Gopinath et al.pdf |
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Creator | admin |
Created On: | 03/17/2012 00:00 |
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Last updated on | 04/22/2012 11:28 |
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