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ORIGINAL ARTICLE
D. M. Christe1*,M. P. Kanchana2
1 Medical Research Officer, Indian Council of Medical Research, HRRC, NIRRH-FU,Mumbai, India
2 Department of Gynaecology and Pathology, Institute of Obstetrics and Gynaecology, Madras Medical College, Chennai, India
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*D. M. Christe, MBBS DGO PhD, Indian Council of Medical Research, HRRC,NIRRH-FU, Institute of Obstetrics and Gynaecology, Chennai, India
Article citation: Christe DM, Kanchana MP. Impact of cervical cancer screening in a referral centre. J Pharm Biomed Sci 2016;06(06):360–362. Available at www.jpbms.info
ABSTRACT
Settings Our centre is a public referral and treatment centre situated in the Chennai metropolis. The analysis of the number of women diagnosed with cervical cancer at our centre was performed to find out the impact of low-cost cervical cancer screening in bringing down the incidence of cervical cancer.
Aim To find out the number of women diagnosed with cervical cancer over the past 3 years from 2011 to 2013, in a referral centre in Chennai, to assess the impact of the ongoing cervical cancer screening program.
Methods The number of women diagnosed with cervical cancer and gynaecological cancer from 2011 to 2013 were noted from the records of histopathological reports and maintained in the colposcopy and pathology departments.
Results In 2011, the number of women diagnosed with cervical cancer was 782. The majority of 739 women had squamous cell carcinoma and a less number of 43 women had adenocarcinoma. The following year 2012, the number of women with cervical cancer showed a promising decrease to a total of 672, and further decreased to 599 in 2013. Squamous cell carcinoma was diagnosed in 655 women in 2012 and 575 women in 2013. In the year 2011, the number of women with squamous cell cancer was larger in the age group of 50–60 years, and the largest numbers of women with adenocarcinoma were in the age group of 41–50 years. There was a significant reduction in the incidence of cervical cancer in all the 3 years (P < 0.0000001).
A fall in the percentage of cervical cancer among total gynaecological cancers was also observed.
Conclusion A significant reduction was observed in the incidence of cervical cancer over the past 3 years. The ongoing State Cervical Cancer Screening program could probably have contributed to effect this change.
KEYWORDS incidence of cervical cancer, cervical cancer screening, cancer of cervix
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Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Sources of funding: None.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
REVIEW ARTICLE
Sarika Srivastava1,Priya Ranjan Kumar2*,Santosh Kumar Mishra2
1 Assistant Professor, IMS Ghaziabad (University Courses Campus), NH24, Adhyatmik Nagar, Ghaziabad, UP, India
2 Assistant Professor, IMS Engineering College, NH24, Adhyatmik Nagar, Ghaziabad, UP, India
Address reprint requests to
*Priya Ranjan Kumar, Assistant Professor, IMS Engineering College, NH24, Adhyatmik Nagar, Ghaziabad, UP, India
Article citation: Srivastava S, Kumar PR, Mishra SK. Identification of metabolites through GC/LC–MS processed data using different reference libraries and their comparison. J Pharm Biomed Sci 2016;06(06):363–368. Available at www.jpbms.info
ABSTRACT
Much significant advancement has been reported in the last few years in the field of metabolomics studies. The high-end computer applications are already contributing to the research and analysis in the field of life sciences. There are many hardware and softwares available, which can be used with various biomolecular separation and analysis instruments like chromatography, mass spectroscopy (MS), NMR, etc. The metabolite identification is the crucial part of the metabolomics study. The biosample collected from any resource need to be analysed from GC/LC–MS or NMR-type instrumentation to precisely identify the compounds present in the sample qualitatively and quantitatively. There are many tools and databases already available which can be used for the pre-processing, processing and analysis of raw data generated from these instruments. Various reference libraries are also available, which can be used for the identification of metabolites present in the sample after the processing of raw data. In this study, we have reviewed and compared different libraries and tools available for the metabolite identification from GC/ LC–MS data.
KEYWORDS metabolomics, reference libraries, GC–MS, LC–MS, metabolite profiling
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Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Sources of funding: None.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Original article
MinSong1,Mei-HuaGao1,2,Wei-Huan Huang1,Man-Mei Li1,Hua Li2,Yao-Lan Li1,Xiao-Qi Zhang1*,Wen-Cai Ye1
1 Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China
2 Guangdong Institute for Food and Drug Control, Guangzhou 510180, China
Address reprint requests to:
*Xiao-Qi Zhang,
College of Pharmacy, Jinan University, No. 601 West Huangpu Avenue, Guangzhou 510632, China
Article citation: MinSong, Mei-HuaGao, Huang WH, Li MM, Li H, Li YL, et al.Flavonoids from the seeds of Hovenia acerba and their in vitro antiviral activity. J Pharm Biomed Sci 2016;06(06):401–409.Available at www.jpbms.info
ABSTRACT
A new flavonoid, 6″′-acetyl-spinosin (12), together with 14 known flavonoids, were isolated from Hovenia acerba. Their structures were elucidated by extensive spectroscopic methods. The rotamers of four flavonoid C-glycosides 12–15 was investigated for the first time. All the flavonoids were evaluated for their anti-RSV activity by cytopathic effect (CPE) reduction assay. As a result, five flavonoids, 3, 7, 10, 13, and 14, displayed better antiviral effect against three RSV strains. Plaque reduction assay demonstrated that compound 13 mainly inhibited the intracellular replication of RSV. HPLC analysis indicated that the active compounds 3, 7, and 13 had higher contents in the seeds.
KEYWORDS Hovenia acerba, Rhamnaceae, flavonoids, antiviral activity, RSV
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Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: This work was supported by grants from the National Natural Science Foundation (No. 81373935), the Science and Technology Planning Project of Guangdong Province (No. 2013A022100028), and the Administration of Traditional Chinese Medicine of Guangdong Province (No. 20131139).
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Research article
Wen Hou,Ping-Hua Sun,Zhi-Zhong Geng,Hong-Gui Xu,Jing Lin,Wei-Min Chen*
College of Pharmacy, Jinan University, Guangzhou 510632, China
Address reprint requests to:
*Wei-Min Chen, Department of Medicinal Chemistry, College of Pharmacy, Jinan University, Guangzhou 510632, China
Article citation: Hou W, Sun PH, Geng ZZ, Xu HG, Lin J, Chen WM. Design, synthesis and antibacterial assay of pinosylvin acid derivatives. J Pharm Biomed Sci 2016;06(06):369–373. Available at www.jpbms.info
Abstract:
In this study, a series of Pinosylvin acid (PA) derivatives 3a-3g and 4e were designed and synthesized from 2-acetoxy-6-((diethoxyphosphoryl)methyl)-4-methoxybenzoate and aromatic aldehyde. All structures of target PA derivatives 3a-3g and 4e were characterized by 1H-NMR and MS. Corresponding in vitro antibacterial activities were evaluated by broth dilution method. Among 3a-3g, derivative 3e exhibited potent antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis and MRSA, with a value of MIC against MRSA reaching 16 g/mL. Another type of target compound, 4e, was optimized from 3e by structural modification. Its corresponding value of MIC against MRSA was up to 0.5•g/mL, which was 32-fold stronger than that of norfloxacin. Meanwhile, cytotoxic assay revealed 4e possessed a good selective index between bacterial and normal cells, indicating the potential apply of 4e as an antibacterial agent in clinical application. Based on this preliminary achievement, further investigations including in vivo antibacterial effect and in vivo toxicity tests are still in process.
KEYWORDS antibacterial activity, MRSA, pinosylvin acid derivatives, synthesis.
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Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None.
Competing interest / Conflict of interest: The authors have no financial conflicts of interest.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
ORIGINAL ARTICLE
Min Yang,S-Shan Zhou,Y-Zhen Zhang,Guo-hua Cheng*
School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, China, P.C. 510632
Address reprint requests to
*Guo-hua Cheng, School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, China, P.C. 510632
Article citation: Yang M, Zhou SS, Zhang YZ, Cheng GH. A systematic review for the contraceptive efficacy and safety of compound left acetylene progesterone tablets. J Pharm Biomed Sci 2016;06(06):381–386. Available at www.jpbms.info
ABSTRACT
Background and Objectives There is limited information on the efficacy and safety of compound left acetylene progesterone tablets (LNG/EE 100/20 μg) in contraception. To evaluate the efficacy and safety of LNG/EE 100/20 μg for contraception.
Method We searched the medical databases including Pubmed, Web of science, EMbase and Cochrane library through computer; extracted and evaluated the data then performed the meta-analysis by using Review Manager 5.3 software.
Result A total of seven randomised controlled trials including 1786 subjects were recruited for meta-analysis. Compared with other compound oral contraceptives, LNG/EE 100/20 μg showed no significant differences in contraception efficacy [OR = 1.08, 95% CI (0.29, 4.04), P = 0.91] and safety [OR = 0.99, 95% CI (0.81, 1.21), P = 0.92]; however, it is better than the other compound oral contraceptives on cycle control efficacy of short cycle [OR = 1.75, 95% CI (1.28, 2.38), P = 0.0004].
Conclusion LNG/EE 100/20 μg were better than the other compound oral contraceptives on cycle control of short cycle, and showed no significant differences in the efficacy and safety.
KEYWORDS compound left acetylene progesterone tablets; contraception; efficacy; safety; meta-analysis
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