DocumentsDate added
Original research article:-
*Veerendra K. Nanjwade1, F. V. Manvi1, Shamrez Ali. M2, Basavaraj K. Nanjwade1
1.Department of Pharmaceutics, KLE University College of Pharmacy, JN Medical College Campus, Belgaum – 590010, Karnataka, India.
2.Simpex Pharma Pvt. Ltd, Sigaadi, Kotdwara – 246149, Pauri Garhwal, Uttarakhand, India.
Abstract:-Pharmaceutical cocrystals are new solid forms with physicochemical properties that appear promising for drug product development.
Objective: In this study, we aimed to characterize the of Prulifloxacin-salicylic acid cocrystals by IR, DSC and PXRD in comparision with the pure drug.
Materials and Methods: Pharmaceutical cocrystals were prepared by the kneading method with aid of salicylic acid and urea as coformer. The cocrystals were subjected to various physicochemical studies and thermal methods.
Results and Discussion: The cocrystal of prulifloxacin , with salisylic acid (SA) has been shown to have higher solubility than prulifloxacin. In this study, we aimed to characterize the pure drug and the cocrystals with the salicylic acid and urea. Remarkably, two new cocrystals of prulifloxacin were discovered in this study. The study indicates that the improved aqueous solubility of the cocrystals leads to improved dissolution of Prulifloxacin. Thus, the cocrystals are a viable alternative solid form that can improve the dissolution rate and bioavailability of poorly soluble drugs.
Conclusion: Subsequently, differential scanning calorimetry was used to investigate the cocrystal formation. The formation of cocrystals was also verified using liquid-assisted grinding. The spectral patterns of prulifloxacin , salicylic acid and the complex were different.The physicochemical properties such as solubility and dissolution rate of this complex will be further investigated.
Key words: Pharmaceutical cocrystlas, Prulifloxacin, Salicylic acid, Complex.
Review article:-
A B Roge*, S N Firke, S B Gaikwad, V N Gunjkar, Dr. S M Vadvalkar Pharmaceutical Chemistry Department, Nanded Pharmacy College, Shyam Nagar, Nanded,India.
Abstract:-Bioadhesion is the relatively new and emerging concept in drug delivery, Bioadhesion keeps the delivery system adhering to the mucus membrane. Transmucosal drug delivery systems show various merits over conventional drug delivery systems. Bioadhesive polymers facilitate the bioadhesion by their specific properties. In transmucosal drug delivery system, bioadhesive polymer plays major role along with active ingredients. Bioadhesive polymers that adhere to the mucin epithelial surface are effective and lead to significant improvement in drug delivery system. Improvements are also expected for other mucus-covered sites of drug administration. Bioadhesive polymers find application in the eye, nose, and vaginal cavity as well as in the GI tract, including the buccal cavity and rectum. This review focus on Bioadhesion, Important Factors of Bioadhesion, Ideal Characteristics, Classification, Description and Application of bioadhesive polymer.
Keywords:-Bioadhesion, Mucin, Rectum, Transmucosal drug delivery systems.
Review article:-
*Baiju Gopalan Nair 1 K Amarendhar Reddy 1, Naga Lakshmi Reddy 1, Upendranath Reddy1
1Department of Conservative Dentistry & Endodontics,G Pulla Reddy Dental College & Hospital, Kurnool ,Andhrapradesh, India.
Abstract:-The success in endodontics depends on complete eradication of microbes from the root canal system which effectively prevents re infection. the introduction of rotary instruments help the canal preparation more effective especially in the apical third, there by helping the effectiveness of the irrigants to penetrate till the root apex. This helped to control the microbial level at the apical third of the root canals. The irrigants which use to be delivered using the traditional methods like syringes and needles of different size and tip design prove d to be ineffective. In the recent years, chemical composition of irrigants and mechanical devices which helps in irrigation has been improved leaps and bounds. This article summarizes the recent developments for the safe and effective irrigation which ultimately helps to minimize the bacterial levels resulting in successive endodontic therapy.
Key words:-Root canal Irrigants, Root canal disinfection, Smear layer, Endovac- irrigating system, PUI, Lasers, Quantec-e irrigation system, Bioglasses, Ozone therapy.
Original research article:-
*Jothieswari. D1,2 , Anandakumar. K2, Vijaya Santhi. D3, Vijayakumar. B4, Priya. D4,Stephen Rathinaraj. B5
1.Department of Pharmaceutical Analysis, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.
2.Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur, Tamilnadu, India.
3.Department of Pharmaceutical Analysis, M.A.M College of Pharmacy, Kesanupalli, Guntur, Andhra Pradesh, India.
4.Department of Pharmaceutical Chemistry, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.
5.Department of Pharmaceutical Analysis, Vaagdevi College of Pharmacy, Warangal, Andhra Pradesh, India.
Abstract:- A simple, accurate, precise, economical and reproducible UV spectrophotometric method has been developed for the simultaneous estimation of amlodipine besylate, valsartan and hydrochlorothiazide in bulk and in combined tablet dosage form. The stock solutions were prepared in methanol followed by the further required dilutions with distilled water. This method involves the formation and solving of simultaneous equations at 239 nm, 250 nm and 272 nm, as absorbance maxima of amlodipine besylate, valsartan and hydrochlorothiazide, respectively. Beer’s law obeyed the concentration range of 1 – 32 mcg/ mL, 4 – 40 mcg/ mL and 2 – 20 mcg/ mL for amlodipine besylate, valsartan and hydrochlorothiazide, respectively. The results of analysis were validated statistically and by recovery studies. The % RSD for the recovery study was less than 2. The proposed method can be effectively applied for the simultaneous estimation of these three drugs in bulk and in combined tablet dosage form.
Keywords:- Amlodipine Besylate, Valsartan, Hydrochlorothiazide, Simultaneous equation method, Method validation.
Original research article:-
Monika Gupta* Department of Chemistry, University of Jammu, Jammu-180 006, India.
Abstract:-A simple and fast procedure is developed for the one-pot synthesis of novel 8-methyl-3,6,8-trisubstituted-7H,9H-[1,2,4]triazolo[4,3-b][1,2,4]triazepines from 5-aryl-3,4-diamino-1,2,4-triazoles and acetophenone or substituted acetophenones in the presence of catalytic amount of p-TsOH and N,N-dimethylformamide as an energy transfer medium as well as homogenizer using microwave irradiation as well as by stirring at 800C in a pre-heated oil-bath. Comparative method is simple, fast and economic and gives moderate to good yields of products and are in a state of high purity. Some of these compounds are evaluated for antifungal activity.
Keywords:-Acetophenones, triazoles, triazepines, triazolo-triazepines, N,N-dimethylformamide, p-TsOH, microwave activation.